The proposed study utilizes novel electronics and microfabrication techniques to create scalable, in-vitro Multielectrode Array (MEA) technologies. This research will enable rapid advancements in the study of neural interactions and in the understanding and treatment of neural disorders. Phase I involves two significant developments for neural related research. Specifically, Aim 1 will develop scalable simultaneous stimulation and recording electronics to recover signals traditionally obscured by stimulation artifacts. The recovered data, combined with the ability to simultaneously interact with hundreds of electrodes, will provide new measures of single-cell and network-level neural activity.
Aim 2 will produce scalable and inexpensive multi- well MEAs, which can be used in conjunction with the electronics developed in Aim 1 to yield a high- throughput neural toolset. Phase 2 will generate further increases in scale, while providing data manipula- tion algorithms along with real-time information extraction and control tools. This research uses novel electronic and fabrication technologies to create faster, lower-cost methods for neural research. Ultimately, this development will facilitate medical and scientific discoveries that will benefit the treatment of neural disorders such as Parkinson's and epilepsy. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43NS062477-01
Application #
7482029
Study Section
Special Emphasis Panel (ZRG1-BST-F (10))
Program Officer
Pancrazio, Joseph J
Project Start
2008-07-15
Project End
2009-11-30
Budget Start
2008-07-15
Budget End
2009-05-31
Support Year
1
Fiscal Year
2008
Total Cost
$235,601
Indirect Cost
Name
Axion Biosystems, LLC
Department
Type
DUNS #
802587035
City
Atlanta
State
GA
Country
United States
Zip Code
30332