The objective of this proposal is to design, develop, and validate a commercially viable human-use smart 128-channel macro & micro ECoG microsystem with integrated recording, stimulation, and impedance measuring capabilities for epilepsy monitoring. The microsystem comprises of a state-of-art microelectronic signal processing component linked to a macro & micro integrated ECoG grid via a thin, highly flexible, bio- compatible micro-ribbon cable on one end and a single percutaneous flexible-cable (pigtail) on the other end. The custom multiplexing ASIC electronics is capable of 128-channel recordings at 16-bit resolution and has fast settle capability (for stimulation option) and patient safety circuitry. The component is contained on a printed circuit board and is encapsulated with Parylene-C and Silicone. The encapsulated microelectronic component unit is encased in a titanium case and resides subcutaneously between the skin and the skull. The integrated microsystem would have unique snow-flake shape grid design containing alternate rows of macro and micro channels. The phase-I would target a short-term goal of developing, bench testing and validating in adult sheep model the complete implantable ECoG microsystem that can be translated to research and clinical lab in the shortest time frame.

Public Health Relevance

The objective of this proposal is to design, develop, and validate a commercially viable 'human-use' thin film polymer based smart 128-channel macro & micro integrated ECoG array system for epilepsy monitoring

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
5R43NS093729-02
Application #
9085458
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Langhals, Nick B
Project Start
2015-06-15
Project End
2017-05-31
Budget Start
2016-06-01
Budget End
2017-05-31
Support Year
2
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Blackrock Microsystems
Department
Type
DUNS #
827132015
City
Salt Lake City
State
UT
Country
United States
Zip Code
84108