Direct brain injection of radical-scavenging dyes (e.g. Prussian blue) prevents and cures Alzheimer?s disease in animal models. In human tests of orally administered blue dyes, however, reaching therapeutic concentration levels in the brain has not been achievable. Our published rodent experiments have shown that helical magnetic fields can drill magnetic nanorods from the nose into the brain with very high efficiency. Rodent studies have shown no toxicity after 30-days of particle implantation. In the first phase of this fast- track project, we will validate that our magnetic drilling methods can deliver therapeutic levels of blue dye in the brain non-invasively. In the second phase we will verify that this delivery method improves cognition in a rodent model of Alzheimer disease (AD). Accomplishment of this goal will pave the way to human studies, aided by already- committed investors in the project and by experienced academic partners with whom we have worked for over a decade.

Public Health Relevance

Direct brain injection of radical-scavenging dyes (e.g. Prussian blue) prevents and cures Alzheimer?s disease in animal models. In human tests of orally administered blue dyes, however, reaching therapeutic concentration levels in the brain has not been achievable. Our published rodent experiments have shown that helical magnetic fields can drill magnetic nanorods from the nose into the brain with very high efficiency. In the first phase of this fast-track project, we will validate that our magnetic drilling methods can deliver therapeutic levels of blue dye in the brain non-invasively. In the second phase we will verify that this delivery method improves cognition in a rodent model of Alzheimer disease (AD). Accomplishment of this goal will pave the way to human studies, aided by already- committed investors in the project and by experienced academic partners with whom we have worked for over a decade.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
1R44AG066386-01
Application #
9908814
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Martin, Zane
Project Start
2019-09-15
Project End
2020-08-31
Budget Start
2019-09-15
Budget End
2020-08-31
Support Year
1
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Weinberg Medical Physics, LLC
Department
Type
DUNS #
809594661
City
North Bethesda
State
MD
Country
United States
Zip Code
20852