The need for novel antibiotics has never been greater. Infectious diseases have become the third leading cause of death in the U.S. The rate of mortality from bacterial infections is increasing every year. One reason for this rise is the development of widespread resistance to currently available antibiotics. We plan to combat this rise in its antibiotic resistance by identifying inhibitors of a novel bacterial targets thereby generating new classes of antibiotics. RNase P is an excellent candidate for a target based antibiotic development program because it's function is essential for bacterial survival. The structure of RNase P is highly conserved among bacteria and is substantially diverged from the corresponding human enzyme. During the Phase I period, we developed and validated a high throughput assay to screen for inhibitors of RNase P. Phase II activities will include high throughput screening of RNaseP, characterization of inhibitors, and optimization of compounds to improve potency and antimicrobial activity.

Proposed Commercial Applications

Antibiotics currently constitute a market in the U.S. of nearly 22 billion dollars annually. This research will provide compounds that can be developed into clinically useful antibiotics that can be used to treat bacterial infections by bacteria that are resistant to current antibiotics.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
2R44AI041799-02
Application #
2776813
Study Section
Special Emphasis Panel (ZRG5-MBC-1 (01))
Program Officer
Tseng, Christopher K
Project Start
1997-07-01
Project End
2001-08-31
Budget Start
1999-09-30
Budget End
2000-08-31
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Cubist Pharmaceuticals, Inc.
Department
Type
DUNS #
City
Lexington
State
MA
Country
United States
Zip Code
02421