Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
3R44AI048990-03S1
Application #
6910342
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Sharma, Opendra K
Project Start
2001-05-01
Project End
2006-07-31
Budget Start
2003-08-01
Budget End
2004-07-31
Support Year
3
Fiscal Year
2004
Total Cost
$200,000
Indirect Cost
Name
Monogram Biosciences, Inc.
Department
Type
DUNS #
945494490
City
South San Francisco
State
CA
Country
United States
Zip Code
94080
Huang, Wei; Frantzell, Arne; Toma, Jonathan et al. (2011) Mutational pathways and genetic barriers to CXCR4-mediated entry by human immunodeficiency virus type 1. Virology 409:308-18
Bunnik, Evelien M; Swenson, Luke C; Edo-Matas, Diana et al. (2011) Detection of inferred CCR5- and CXCR4-using HIV-1 variants and evolutionary intermediates using ultra-deep pyrosequencing. PLoS Pathog 7:e1002106
Toma, Jonathan; Weinheimer, Steven P; Stawiski, Eric et al. (2011) Loss of asparagine-linked glycosylation sites in variable region 5 of human immunodeficiency virus type 1 envelope is associated with resistance to CD4 antibody ibalizumab. J Virol 85:3872-80
Toma, Jonathan; Whitcomb, Jeannette M; Petropoulos, Christos J et al. (2010) Dual-tropic HIV type 1 isolates vary dramatically in their utilization of CCR5 and CXCR4 coreceptors. AIDS 24:2181-6
Huang, Wei; Eshleman, Susan H; Toma, Jonathan et al. (2009) Vertical transmission of X4-tropic and dual-tropic HIV-1 in five Ugandan mother-infant pairs. AIDS 23:1903-8
Huang, Wei; Toma, Jonathan; Stawiski, Eric et al. (2009) Characterization of human immunodeficiency virus type 1 populations containing CXCR4-using variants from recently infected individuals. AIDS Res Hum Retroviruses 25:795-802
Fransen, Signe; Bridger, Gary; Whitcomb, Jeannette M et al. (2008) Suppression of dualtropic human immunodeficiency virus type 1 by the CXCR4 antagonist AMD3100 is associated with efficiency of CXCR4 use and baseline virus composition. Antimicrob Agents Chemother 52:2608-15
Mohri, Hiroshi; Markowitz, Martin (2008) In vitro characterization of multidrug-resistant HIV-1 isolates from a recently infected patient associated with dual tropism and rapid disease progression. J Acquir Immune Defic Syndr 48:511-21
Huang, Wei; Toma, Jonathan; Fransen, Signe et al. (2008) Coreceptor tropism can be influenced by amino acid substitutions in the gp41 transmembrane subunit of human immunodeficiency virus type 1 envelope protein. J Virol 82:5584-93
Huang, Wei; Eshleman, Susan H; Toma, Jonathan et al. (2007) Coreceptor tropism in human immunodeficiency virus type 1 subtype D: high prevalence of CXCR4 tropism and heterogeneous composition of viral populations. J Virol 81:7885-93

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