Benoxaprofen is effective in the systemic treatment of psoriasis but is toxic. One of the goals of this application is to modify benoxaprofen for topical administration which should result in high concentrations at the lesion site, lower concentrations systemically, and improved safety. Thirteen compounds have been evaluated in the arachidonic acid mouse ear inflammation assay. Four of our compounds are more active than benoxaprofen in this model. 3890902 was more active (0.2
