The scientific and commercial goal of this small business innovation research (SBIR-Phase II) proposal is to develop cell-based assays for the detection of biologically active complementary and alternative medicine (CAM) agents in body fluids. The proposed project builds on the foundation of a molecular assay designed and validated through a recent Phase I funding. The strategy of identifying CAM agents in body fluids by an in vitro bio-luminescence imaging system complements another drug-discovery technology developed at Swaasth Inc, referred to as Genetic Expression and Measurement (GEMTM). Together, these cell-based CAM agent detection technologies will enable the development of novel technologies in monitoring objective measures of adherence to study-protocol in the investigations of CAM modalities. Swaasth Inc. has ? successfully developed molecular reagents and high throughput-screening infrastructure required to ? identify CAM agents. It is anticipated that the availability of GEM system will make effective use of ? the Phase II funding to further expand the detection of a variety of CAM agents and enhance ? minimally invasive patient adherence measurements for CAM modalities in clinical settings. ? ? ?
|Septer, Seth; Lawson, Caitlin E; Anant, Shrikant et al. (2016) Familial adenomatous polyposis in pediatrics: natural history, emerging surveillance and management protocols, chemopreventive strategies, and areas of ongoing debate. Fam Cancer 15:477-85|
|Dimas, Konstantinos; Tsimplouli, Chrisiida; Houchen, Courtney et al. (2015) An Ethanol Extract of Hawaiian Turmeric: Extensive In Vitro Anticancer Activity Against Human Colon Cancer Cells. Altern Ther Health Med 21 Suppl 2:46-54|
|Pantazis, Panayotis; Dimas, Konstantinos; Wyche, James H et al. (2012) Preparation of siRNA-encapsulated PLGA nanoparticles for sustained release of siRNA and evaluation of encapsulation efficiency. Methods Mol Biol 906:311-9|
|Sureban, Sripathi M; May, Randal; Mondalek, Fadee G et al. (2011) Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism. J Nanobiotechnology 9:40|
|Pantazis, Panayotis; Varman, Aarthi; Simpson-Durand, Cindy et al. (2010) Curcumin and turmeric attenuate arsenic-induced angiogenesis in ovo. Altern Ther Health Med 16:12-4|
|Ponnurangam, Sivapriya; Mondalek, Fadee G; Govind, Janita et al. (2010) Urine and serum analysis of consumed curcuminoids using an IkappaB-luciferase surrogate marker assay. In Vivo 24:861-4|