The objective of this project is to develop an imaging system to allow visualization of small cancerous tumors and guide biopsy of the prostate. In the course of the Phase l R43CA96153 project and subsequent development sponsored by private funds, we defined the parameters for a commercially viable laser optoacoustic imaging system (LOIS-P) for detection of prostate cancer and developed the first laboratory prototype suitable for phantom testing and experiments in dogs. Our initial test results encouraged the submission of a Phase ll proposal for development of a commercial prototype of LOIS-P and its extensive evaluation in the canine model of prostate cancer. This system will operate in real time and will be capable of imaging the prostate gland and guiding a biopsy procedure. Current methods of medical imaging are only marginally successful in differentiating between cancerous and normal prostate tissue. As a result, biopsies are typically performed with random sampling of tissue throughout the prostate (yielding about a 30% false negative rate). Optoacoustic imaging utilizes the highest known physical or chemical contrast of cancerous tissues relative to normal or benign tissue based on absorption of blood in the tumor microvessels and provides images with excellent resolution of 0.5 mm typical of ultra wide-band ultrasonic imaging. Based on imaging results from 25 breast cancer patients, LOIS has already demonstrated clinical feasibility in diagnostic imaging of malignant tumors in the breast. We will utilize experience gained in the continuing Phase-ll project for development of a clinical breast imaging system to develop a more advanced system for guiding biopsy of the prostate. The focus of the 1st year project will be on development and fabrication of (1) a transrectal probe incorporating a fiberoptic light delivery system with an array of 128 ultrawide-band ultrasonic transducers and charge preamplifiers, and (2) a beam forming and data acquisition and processing circuit board with firmware capable of dual imaging with conventional ultrasound and optoacoustics. The 2nd year will be dedicated to extensive evaluation of transrectal LOIS-P in a canine model of prostate cancer and iterative optimization of the developing system in preparation for clinical testing in humans. Successful accomplishment of the proposed project will make the optoacoustic imaging system available for clinical evaluation as a feature of a transrectal ultrasound system. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
2R44CA096153-02
Application #
7111584
Study Section
Special Emphasis Panel (ZRG1-SBMI-F (11))
Program Officer
Farahani, Keyvan
Project Start
2002-09-30
Project End
2008-04-30
Budget Start
2006-05-16
Budget End
2007-04-30
Support Year
2
Fiscal Year
2006
Total Cost
$538,769
Indirect Cost
Name
Fairway Medical Technologies, Inc.
Department
Type
DUNS #
944316967
City
Houston
State
TX
Country
United States
Zip Code
77024
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Jiang, Z; Piao, D; Bartels, K E et al. (2011) Transrectal ultrasound-integrated spectral optical tomography of hypoxic progression of a regressing tumor in a canine prostate. Technol Cancer Res Treat 10:519-31
Fronheiser, Matthew P; Ermilov, Sergey A; Brecht, Hans-Peter et al. (2010) Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature. J Biomed Opt 15:021305
Yaseen, Mohammad A; Ermilov, Sergey A; Brecht, Hans-Peter et al. (2010) Optoacoustic imaging of the prostate: development toward image-guided biopsy. J Biomed Opt 15:021310
Conjusteau, André; Ermilov, Sergey A; Su, Richard et al. (2009) Measurement of the spectral directivity of optoacoustic and ultrasonic transducers with a laser ultrasonic source. Rev Sci Instrum 80:093708