? The future of optical coherence tomography (OCT) in research and clinical medicine depends, to a large extent, on the development of better light sources. Portable sources with much wider bandwidths and higher single mode power are required to achieve the long standing goal of subcellular imaging in highly scattering tissue for detection and staging of endothelial cancers. Additionally, greater flexibility of center wavelength is required for assessment of tissue composition. ? ? This work aims to employ semiconductor wafer bonding technology to create high power, broadband, spectrally shaped, single-chip superluminescent diode (SLD) sources for OCT. This technology enables the in-line integration of several SLD sources comprising different composition emitter regions and operating at different spectral bands. The proposed geometry potentially allows superposition of 4-8 spectral bands with arbitrary weighting of each band, and promises to overcome the inherent losses in existing spectral synthesis techniques. The target specifications for these sources are greater than 200 nanometer (nm) bandwidth and greater than10 milliwatt (mw) fiber coupled power, out of a single chip. If successfully fabricated, this compact device will present researchers and emerging OCT manufacturers with unprecedented depth resolution in tissue imaging applications, enable spectroscopic OCT, and ideally increase the proliferation of high-resolution OCT research. ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
5R44CA101067-03
Application #
7025812
Study Section
Special Emphasis Panel (ZCA1-SRRB-9 (J2))
Program Officer
Baker, Houston
Project Start
2005-02-28
Project End
2007-12-31
Budget Start
2006-01-01
Budget End
2006-12-31
Support Year
3
Fiscal Year
2006
Total Cost
$485,254
Indirect Cost
Name
Praevium Research, Inc.
Department
Type
DUNS #
132398913
City
Santa Barbara
State
CA
Country
United States
Zip Code
93111
Liang, Kaicheng; Ahsen, Osman O; Wang, Zhao et al. (2017) Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source. Opt Lett 42:3193-3196
Lee, Hsiang-Chieh; Ahsen, Osman O; Liang, Kaicheng et al. (2017) Endoscopic optical coherence tomography angiography microvascular features associated with dysplasia in Barrett's esophagus (with video). Gastrointest Endosc 86:476-484.e3
Liang, Kaicheng; Ahsen, Osman O; Lee, Hsiang-Chieh et al. (2016) Volumetric Mapping of Barrett's Esophagus and Dysplasia With en face Optical Coherence Tomography Tethered Capsule. Am J Gastroenterol 111:1664-1666
Lee, Hsiang-Chieh; Ahsen, Osman Oguz; Liang, Kaicheng et al. (2016) Circumferential optical coherence tomography angiography imaging of the swine esophagus using a micromotor balloon catheter. Biomed Opt Express 7:2927-42
Ahsen, Osman O; Lee, Hsiang-Chieh; Giacomelli, Michael G et al. (2014) Correction of rotational distortion for catheter-based en face OCT and OCT angiography. Opt Lett 39:5973-6
Tsai, Tsung-Han; Ahsen, Osman O; Lee, Hsiang-Chieh et al. (2014) Endoscopic optical coherence angiography enables 3-dimensional visualization of subsurface microvasculature. Gastroenterology 147:1219-21
Zhang, Ning; Tsai, Tsung-Han; Ahsen, Osman O et al. (2014) Compact piezoelectric transducer fiber scanning probe for optical coherence tomography. Opt Lett 39:186-8
Ahsen, Osman O; Tao, Yuankai K; Potsaid, Benjamin M et al. (2013) Swept source optical coherence microscopy using a 1310 nm VCSEL light source. Opt Express 21:18021-33
Grulkowski, Ireneusz; Liu, Jonathan J; Zhang, Jason Y et al. (2013) Reproducibility of a long-range swept-source optical coherence tomography ocular biometry system and comparison with clinical biometers. Ophthalmology 120:2184-90
Lee, Hsiang-Chieh; Liu, Jonathan J; Sheikine, Yuri et al. (2013) Ultrahigh speed spectral-domain optical coherence microscopy. Biomed Opt Express 4:1236-54

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