Significance: Robotic radiotherapy using extensively non-coplanar beams has been shown effective to significantly improve radiation therapy dosimetry, leading to improved treatment outcomes. However, the current implementation of this technique by CyberKnife is inefficient and not dosimetrically optimal. This has severely limited both the number of patients eligible for robotic radiotherapy and the achievable clinical outcome for those who have been treated. In order to overcome these limitations, a novel robotic radiotherapy system will be developed that can efficiently utilize the full potential of the non-coplanar delivery space to treat the majority of radiotherapy patients. Innovation: The proposed system is highly innovative in the following aspect: 1) Integrated beam orientation and fluence optimization. 2) Significantly more compact linac to allow posterior beams. 3) Flexible field sizes and MLC resolution to efficiently treat most target sizes. 4) Volumetric imaging and real-time IGRT will be implemented. This project is proposed to design the hardware and software platforms materializing such a robotic radiotherapy system. In order to reduce the gantry size, both the linac length and the distance between the source and the MLC need to be significantly reduced. A new 3 MV source has been designed to reduce linac length and provide the required dose rate for treatment. The physical MLC leaf thickness cannot be substantially thinner than 1 mm. To achieve a high MLC resolution at the treatment distance, a spacer is used in CyberKnife between the primary collimator and the MLC, increasing the gantry dimension. This proposed system will eliminate the spacer but vary the focus-to-tumor distances (FTD) to achieve desired field size and MLC resolution. This requires optimization in an enormous solution space, a capacity uniquely demonstrated by the 4? algorithm.
Aims : 1a: Build the 3MV linac that can produce 800 cGy/min at 100 cm. 1b. Mount the linac on an industrial robot and test its mechanical robustness. 1c. Integrate a micro multi-leaf collimator (MLC). 2a. Develop a global optimal direct aperture solution for the static intensity modulated radiotherapy (IMRT). 2b. Develop a global volumetric modulated arc therapy (gVMAT) solution. 2c. Develop a navigation algorithm for the robot to travel and deliver the radiation efficiently. 3a. Perform safety and collision model test. 3b. Dosimetry end-to-end testing. 3c. QA test. Impact: Successfully achieving these three aims will provide a prototype to prove the feasibility of the versatile robotic system for radiotherapy. It will be scientifically and clinically significant, positioning the system well for further commercial development.

Public Health Relevance

Success of the proposed project would lead to the development of a novel radiation therapy device capable of significantly reducing the radiation dose deposited to healthy tissue during cancer treatment. The final clinical system to be developed in Phase II would revolutionize the field of radiation therapy by allowing this precise tumor targeting to be achieved with a quick, flexible robotic system enabling high patient throughput. This system is expected to manage a wide range of diseases and treatment fractions, thus having a broad clinical and commercial impact.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
5R44CA183390-04
Application #
9671861
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Evans, Gregory
Project Start
2016-06-19
Project End
2020-03-31
Budget Start
2019-04-01
Budget End
2020-03-31
Support Year
4
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Radiabeam Technologies, LLC
Department
Type
DUNS #
140789137
City
Santa Monica
State
CA
Country
United States
Zip Code
90404
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