The purpose of this research is to develop new titanium alloys for maxillofacial prostheses. Titanium implants have a long history, however there remains considerable potential to optimize their performance for oral and maxillofacial applications. This research will address two significant issues for the development of improved metal implants, namely, the balance of mechanical strength with elasticity, and high-rate osseointegration with long term biocompatiblity. Phase I has demonstrated the feasibility of designing new titanium alloys that retain the desirable strength of commercially available alloys, but provide increased elasticity. Phase II research will pursue an integrated development of new implantable alloys from material synthesis to clinical evaluation. Phase II has for specific aims: 1) develop new high-strength titanium alloys with an increase of elasticity closer to that of bone than present alloys; 2) develop a novel approach to create high Ti content surface textures for better osseointegration; 3) identify promising mechanical properties, corrosion resistant surfaces and in-vitro biocompatibility; and 4) demonstrate desirable osseointegration by in-vivo implant tests. A series of clinical implant tests (rabbit tibia) will be conducted to establish their key benefits as future implantable biomaterial systems based on histological evaluation and pull-out strength measurement. The best alloy/surface system with the highest elasticity will be further evaluated for developing clinically innovative products.

Proposed Commercial Applications

Not Available

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
5R44DE012445-03
Application #
6516496
Study Section
Special Emphasis Panel (ZDE1-PW (70))
Program Officer
Satish, Jaya
Project Start
1998-06-01
Project End
2004-03-31
Budget Start
2002-06-01
Budget End
2004-03-31
Support Year
3
Fiscal Year
2002
Total Cost
$384,473
Indirect Cost
Name
Wamax, Inc.
Department
Type
DUNS #
City
Bellevue
State
WA
Country
United States
Zip Code
98006