(Scanned from the applicant's description) Type 2 diabetes is estimated to affect 16 million people in the U.S. Complications of diabetes impair the longevity and quality of life and include heart disease, stroke, retinopathy, neuropathy and nephropathy. In 1999 the estimated cost of diabetes in the U.S. exceeded $100 Billion. This proposal presents a plan to characterize a new model of Type 2 diabetes and obesity. The BBZDR rat will provide the research community with a superb model with which to study the pathogenesis, prevention, complications and therapy of human diabetes. We will continue to inbreed the rat to eliminate residual heterozygosity, we will employ a variety of hormone replacement and augmentative therapies to overcome the sterility associated with obesity. We will study by time course the development of diabetic dyslipidemia, retinopathy, neuropathy and nephropathy and cardiac restenosis. It is our expectation that this new model of Type 2 diabetes, the most common form of diabetes, will expedite the development of safe and effective pharmaceutical agents for the treatment of this important human disease.

Proposed Commercial Applications

Not available

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
2R44DK053679-02
Application #
6293193
Study Section
Special Emphasis Panel (ZRG1-SSS-T (01))
Program Officer
Abraham, Kristin M
Project Start
1997-09-30
Project End
2002-12-31
Budget Start
2001-01-01
Budget End
2001-12-31
Support Year
2
Fiscal Year
2001
Total Cost
$452,092
Indirect Cost
Name
Biomedical Research Models, Inc.
Department
Type
DUNS #
015341134
City
Worcester
State
MA
Country
United States
Zip Code
01606
Tirabassi, Rebecca S; Flanagan, Joan F; Wu, Tiangen et al. (2004) The BBZDR/Wor rat model for investigating the complications of type 2 diabetes mellitus. ILAR J 45:292-302