Gastrointestinal motility disorders remain significant both in terms of patient symptom prevalence and health care resource use. In diagnosing many such disorders, manometry remains the gold standard because of its sensitivity to motor dysfunction. High-resolution pressure imaging has been shown to provide improved and more reliable diagnoses over conventional methods. Current clinical manometry systems are limited due to their low number of achievable sensors (solid state strain gauge technology) or difficulty of use (water perfused equipment). In Phase I we successfully demonstrated the world's first high-resolution solid-state manometric catheter. The production and test of this prototype with supporting electronics and software exceeded all initially proposed accomplishments of that phase. In Phase 11, we will develop this Motility Visualization System (MVS) into a commercial-ready form, validate it through clinical trials, and obtain FDA approval. The MVS has unique benefits for physicians, clinical technical staff, and patients. The large number of sensors distributed over a relatively long length of the catheter will simplify and shorten the clinical procedure and yield consistent site-to-site motility study results. The graphical visualization software supports rapid and reliable diagnoses. This technology has the power to revolutionize clinical motility practices.

Proposed Commercial Applications

NOT AVAILABLE

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
5R44DK056539-03
Application #
6498160
Study Section
Special Emphasis Panel (ZRG1-SSS-8 (62))
Program Officer
Podskalny, Judith M,
Project Start
2001-02-01
Project End
2004-01-31
Budget Start
2002-02-01
Budget End
2004-01-31
Support Year
3
Fiscal Year
2002
Total Cost
$218,164
Indirect Cost
Name
Pressure Profile Systems, Inc.
Department
Type
DUNS #
City
Los Angeles
State
CA
Country
United States
Zip Code
90045