End-Stage Renal Disease (ESRD) affects just over 600,000 people in the United States and costs Medicare ~$33 billion annually. In-center thrice-weekly hemodialysis is the most commonly performed treatment for ESRD, but it suffers from poor 5-year survival rates, reduced patient quality of life, and is costly. In contrast, frequent hemodialysis has demonstrated 5-year survival rates similar to kidney transplant and has improved intermediate outcomes. Even though frequent hemodialysis yields superior outcomes than in-center thrice- weekly hemodialysis, it is performed by less than 1% of the ESRD population because it is too costly to perform in-center and too complex to perform at home. Current home hemodialysis systems require patients and caregivers to perform complicated tasks associated with life threatening risks, such as self-care needle sticks. The superior outcomes but low adoption rate of frequent home hemodialysis creates an opportunity for a simple-to-use and safe home hemodialysis system. The long-term objective of our project is to create a new home hemodialysis system (the iHemo) that will increase the practice of frequent home hemodialysis and improve End-Stage Renal Disease (ESRD) outcomes.

Public Health Relevance

End-Stage Renal Disease (ESRD) affects over 600,000 people in the US and costs Medicare approximately 33 billion dollars annually. Silicon Kidney is developing a new dialysis treatment that will improve ESRD patient outcomes, increase patient quality of life, and significantly reduce Medicare's expenditures on ESRD.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
2R44DK102240-02
Application #
9623060
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Gossett, Daniel Robert
Project Start
2014-07-01
Project End
2020-07-31
Budget Start
2018-09-15
Budget End
2019-07-31
Support Year
2
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Silicon Kidney, LLC
Department
Type
DUNS #
966332822
City
San Ramon
State
CA
Country
United States
Zip Code
94583