The goal of this project is to develop novel technology for predicting drug-induced kidney injury such as caused by systemic antimicrobials, diuretics, anticancer agents, and anti-inflammatory drugs. Drugs cause approximately 20 percent of community- and hospital- acquired episodes of acute renal failure, but the incidence in older adults may be as high as 60 percent. A significant problem is that while there are many drugs that have the potential to cause drug-induced kidney injury, there are few tools available for prevention of drug-induced kidney injury. Drug-induced kidney injury often occurs prior to detecting alterations in renal function or of biomarkers associated with injury. In this project, we will develop novel technology that can be used to test drugs (preclinical, clinical, or after-market) for potential to cause drug-induced kidney injury. In developing the technology, considered will be the various components and processes underlying pathophysiology associated with acute kidney injury caused by various drugs. Additionally, we will perform validation of this technology. Once validated, the technology will be ready to commercialize, including making the technology available to our existing base of pharmaceutical company customers, to regulatory agencies, and for academic teaching and academic research use.

Public Health Relevance

The goal of this project is to develop technology that can be used to predict the potential of a drug to cause acute kidney injury. The project will provide a tool that can be used to inform preclinical drug development, inform clinical trial designs, predict product safety, evaluate potential adverse event mechanisms, as well as contribute to the understanding of mechanisms involved in drug-induced kidney injury.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
5R44DK118981-03
Application #
9844943
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Gossett, Daniel Robert
Project Start
2018-08-01
Project End
2020-07-31
Budget Start
2020-02-01
Budget End
2020-07-31
Support Year
3
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Dilisym Services, Inc.
Department
Type
DUNS #
080237156
City
Research Triangle Park
State
NC
Country
United States
Zip Code
27709