For patients over 60-years old, cataract surgery with Intraocular lens (IOL) implantation is the most commonly-performed surgical procedure. Unfortunately, the calculation of IOL power is often imprecise due to pre-operative measurement error, post-operative astigmatism from irregular wound healing, or variability in the placement of an IOL. As a result, most cataract patients need to wear spectacles in order to achieve optimal vision. The objective of this project is to develop a light-adjustable Intraocular lens (LAL). The LAL is an IOL whose power can be precisely adjusted with light 2-4 weeks after cataract surgery to correct refractive errors such as tilt, power, and astigmatism which may have been induced by the procedure or through subsequent wound healing. By post-operatively modifying IOL power and precisely correcting refractive error, the LAL will enable cataract patients to predictably achieve best-possible vision without the need for spectacles. The project has three aims: (1)Develop and optimize a silicone LAL composition, including matrix, macromer, photoinitiator, and UV absorber; (2)Optically test and differentiate and LAL via characterization, irradiation protocol, and a treatment nomogram; and (3)Conduct pre-Clinical animal studies regarding the LAL's biocompatibility and safety.
NOT AVAILABLE
| Chayet, Arturo; Sandstedt, Chris; Chang, Shiao et al. (2009) Correction of myopia after cataract surgery with a light-adjustable lens. Ophthalmology 116:1432-5 |
| Schwartz, Daniel M; Sandstedt, Christian A; Chang, Shiao H et al. (2004) Light-adjustable lens: development of in vitro nomograms. Trans Am Ophthalmol Soc 102:67-72; discussion 72-4 |
| Schwartz, Daniel M (2003) Light-adjustable lens. Trans Am Ophthalmol Soc 101:417-36 |
