Abstract

The goal of this fast-track phase I / II proposal is to reduce or eliminate blindness due to rejection of corneal transplants in high risk, penetrating keratoplasty.
The specific aim of the phase I project is to test the efficacy of a cyclosporine implant in a rabbit model of corneal graft rejection. If the implant is ineffective in the rabbit model phase II funds will not be sought. Phase II of this proposal will assess the safety and efficacy of the implant in patients at high risk of graft failure.

Proposed Commercial Applications

NOT AVAILABLE

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
4R44EY012338-02
Application #
6356106
Study Section
Special Emphasis Panel (ZRG1-VISA (02))
Program Officer
Fisher, Richard S
Project Start
1998-09-30
Project End
2002-09-29
Budget Start
2000-09-30
Budget End
2001-09-29
Support Year
2
Fiscal Year
2000
Total Cost
$267,315
Indirect Cost

  Institution

Name
Control Delivery Systems, Inc.
Department
Type
DUNS #
City
Watertown
State
MA
Country
United States
Zip Code
02172