Microwave Thermokeratoplasty (MTK) shrinks the stromal (middle) layer of the cornea in a ring pattern around the pupil in response to elevation of temperature by absorption of microwave energy; the central cornea flattens as a result, thus correcting for myopia. About 50% of the U.S. population requires correction for myopia. This novel method has advantages over the most common surgical treatment for myopia, laser assisted in-situ keratomileusis (LASIK). Specifically, MTK: ? Involves no surgical intervention in the central cornea. ? Requires no period of healing. ? Does not use expensive equipment. ? Involves only a single, 2-second treatment. ? Spares the corneal epithelium through its cooling system. ? Avoids the dry eye complication characteristic of LASIK. We will improve the existing MTK system by incorporating a feedback system to achieve precise results and an optical centering system to assist placement on the cornea. We will evaluate the redesigned system in ex vivo and in vivo corneas and quantify the improvement in predictability and repeatability of refractive effect. In Phase I, we will perform an in vivo acute study in five subjects. In Phase II, we will perform an in vivo chronic study with a 3- month follow-up period. This work will support our application to the FDA for an Investigational Device Exemption.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
1R44EY015085-01
Application #
6694909
Study Section
Special Emphasis Panel (ZRG1-SSS-7 (11))
Program Officer
Helmsen, Ralph J
Project Start
2003-09-01
Project End
2004-08-31
Budget Start
2003-09-01
Budget End
2004-08-31
Support Year
1
Fiscal Year
2003
Total Cost
$117,175
Indirect Cost
Name
Avedro, Inc.
Department
Type
DUNS #
007274362
City
Waltham
State
MA
Country
United States
Zip Code
02451