The applicant organization proposes to develop ultra-miniaturized, minimally invasive test wand methods for quantification in whole blood specimens of methanol, formate, ethylene glycol, and glycolate, the four critical analytes in the laboratory evaluation of toxic alcohol exposure. The methods dose and transport a blood sample in the nanoliter range to an integrated polymeric detection site. The detection site embodies dried chemical reagents capable of reacting with analyte, as well as a polymeric composition capable of absorbing a defined volume of blood plasma while preventing cellular component of blood from penetrating the composition. Cells are wholly removed from the detection site by proprietary chemical and physical mechanisms, thereby obviating the need for a separate cell-filtering material and unmasking the detection site for instrumented or visual analysis. Instrumented analysis is performed by means of a hand-held transmittance monitoring meter. Test procedure and performance time are streamlined by consolidating all testing steps into one single disposable device. Primary target markets are emergency room and other critical care environments. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
2R44GM062145-02A2
Application #
6935153
Study Section
Special Emphasis Panel (ZRG1-SSS-6 (10))
Program Officer
Edmonds, Charles G
Project Start
2000-09-25
Project End
2007-05-31
Budget Start
2005-06-01
Budget End
2006-05-31
Support Year
2
Fiscal Year
2005
Total Cost
$372,983
Indirect Cost
Name
Micronix, Inc.
Department
Type
DUNS #
City
Carmel
State
IN
Country
United States
Zip Code
46032