Acute and chronic pain resulting from injury, surgery, or disease afflicts >100 million Americans each year, having a severe impact on mood, mental health, and quality of life and costing the U.S. approximately $600 billion in economic costs annually. For many patients, treatment options provide inadequate relief because of the shortcomings of available therapeutics. To date, most treatments for pain have been small molecule compounds that block the activity of select ion channels or other pain receptors, but these therapeutics often result in side-effects caused by off-target binding or suffer from poor bioavailability. These limitations have prompted renewed searches for novel targets for the treatment of pain and novel types of inhibitors capable of achieving the specificity and bioavailability needed for a successful therapeutic. The P2X3 ion channel is a primary mediator of pain triggered by ATP release, and drugs that target P2X3 could be efficacious in treating chronic pain. Here we propose to develop MAbs targeting the ion channel P2X3 for the treatment of neuropathic and inflammatory pain.

Public Health Relevance

This proposal will contribute to public health and the cure of human disease by resulting in the development of therapeutic MAbs against P2X3 to treat neuropathic and inflammatory pain. Lead MAbs with confirmed specificity and efficacy will be developed with the goal of entering pre-clinical studies and the filing of an IND for studies in humans.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
5R44GM096500-05
Application #
9130898
Study Section
Special Emphasis Panel (ZRG1-IMST-G (10)B)
Program Officer
Chin, Jean
Project Start
2011-02-01
Project End
2017-02-28
Budget Start
2016-09-01
Budget End
2017-02-28
Support Year
5
Fiscal Year
2016
Total Cost
$215,291
Indirect Cost
Name
Integral Molecular
Department
Type
DUNS #
034055645
City
Philadelphia
State
PA
Country
United States
Zip Code
19104