This application proposes to develop and test a unique laser based catheter system for treatment of ventricular and supraventricular arrhythmias. After successful construction of prototypes and demonstration of effective AV conduction modification in SBIR phase l, the following studies are proposed: 1) optimize catheter development for mapping in the left ventricle 2) evaluate catheter in a canine model of ventricular tachycardia (n=24) 3) compare the effect of laser to radiofrequency in a canine model (n=20) 4) optimize catheter development for AV nodal conduction modification in a canine model (n=12) and 5) start a clinical trial initially for supraventricular and later for ventricular tachycardia. The ALS system has a monitoring feedback system that measures laser penetration depth by ultrasound and tissue temperature. ALS catheters use electrode guidance for a side emitting laser beam which travels in a column of saline solution that clears the path between the catheter and arrhythmia focus. The ALS non-contact laser delivery system provides optimal control and maximizes depth of tissue coagulation. The investigators and consultants submitting this proposal are recognized leaders in the field of lasers, catheter engineering and electrophysiology.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
5R44HL044273-03
Application #
2221413
Study Section
Special Emphasis Panel (SSS (B5))
Project Start
1993-08-01
Project End
1996-04-30
Budget Start
1994-08-01
Budget End
1996-04-30
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Abela Laser Systems, Inc.
Department
Type
DUNS #
City
East Lansing
State
MI
Country
United States
Zip Code
48823