Multielectrode arrays (MEAs) have the potential to bridge the gap between in vivo and in-vitro studies of neuronal networks, However, the engineering required to use MEAs is a burden for most neurophysiology labs. In addition, the biophysical principles underlying the use of MEAs have not been rigorously verified, In this project, Tanner Research-is developing a new, easy-to-use, modular system comprising an electrode array laboratory instrument hardware, and custom software. Our MEA system will allow both recording and real-time feedback stimulation. In an experimental and theoretical effort at Caltech, we are quantitatively charac terizing the biophysics of recording and stimulation with MEAs. Real- time feedback stimulation will be automatically triggered by complex neural activity patterns specified by the researcher. We will sell NEA systems and provide custom electrode-array design and fabrication services to biology labs. Our product will provide more electrodes and greater stimulation capability than a competing system, at a lower price. Furthermore, since it is modular, neurophysiology labs will be able to begin using MEAs with an even smaller budget, and then expand to 128- channel electrode arrays and real-time feedback. In short, this project will improve the understanding of MEA biophysics and make MEAs widely available with enhanced functionality.
Commercial applications for the proposed MEA system include primary neurobiological research at some 500 laboratories nationwide. Additionally, the MEA system has broad applications as a diagnostic tool for studying the affects of drugs and toxins, add has potential for inexpensive and effective drug screening without the use of living animals.
| Claverol-Tinture, Enric; Pine, Jerome (2002) Extracellular potentials in low-density dissociated neuronal cultures. J Neurosci Methods 117:13-21 |
