The development of in vitro models that provide useful, cost-effective tools for assessing long-term electrochemical function of chronically implanted electrodes is proposed. The in vitro models will provide an alternative to animal models for developing experimental protocols and assessing chronic electrode stability. They will allow long-term testing of electrochemical function and stability of electrodes under conditions that reflect the in vivo electrochemical environment without the expense and variability of conducting such testing in animals. The program focuses on electrodes for neural recording, functional electrical stimulation (FES), and chemical sensing in the central nervous system (CNS), although applications to electrodes in the periphery and to biostability of passive implants are anticipated. An inanimate model and a living model employing mouse progenitor cells are proposed. Both models are designed to mimic the compositional and diffusion environment of the CNS as it affects electrochemistry at an electrode. The inanimate model was developed in Phase I. The Phase II program will expand the model to include living cells. The validity of the inanimate and living models will be evaluated by comparison of electrode function in the in vitro models with that observed under identical test protocols in the chronic cat cortex.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
5R44NS039714-03
Application #
6658114
Study Section
Special Emphasis Panel (ZRG1-BDCN-6 (10))
Program Officer
Chen, Daofen
Project Start
2000-04-01
Project End
2005-08-31
Budget Start
2003-09-01
Budget End
2005-08-31
Support Year
3
Fiscal Year
2003
Total Cost
$397,983
Indirect Cost
Name
Eic Laboratories, Inc.
Department
Type
DUNS #
076603836
City
Norwood
State
MA
Country
United States
Zip Code
02062
Cogan, Stuart F (2008) Neural stimulation and recording electrodes. Annu Rev Biomed Eng 10:275-309
Cogan, Stuart F; Troyk, Philip R; Ehrlich, Julia et al. (2007) The influence of electrolyte composition on the in vitro charge-injection limits of activated iridium oxide (AIROF) stimulation electrodes. J Neural Eng 4:79-86
Cogan, Stuart F (2006) In vivo and in vitro differences in the charge-injection and electrochemical properties of iridium oxide electrodes. Conf Proc IEEE Eng Med Biol Soc 1:882-5
Cogan, Stuart F; Troyk, Philip R; Ehrlich, Julia et al. (2005) In vitro comparison of the charge-injection limits of activated iridium oxide (AIROF) and platinum-iridium microelectrodes. IEEE Trans Biomed Eng 52:1612-4