The goal of the current project is to revise a prototype of a computerized attention training program (Amplified Attention Training, AAT) for hemispatial neglect completed in Phase I, and conduct a multi-site, randomized, controlled trial to establish efficacy in this population. As a group, patients with hemispatial neglect tend to have poorer long-term prognosis and are more likely to require managed care than other patient groups with lesions of comparable size. Our recent studies are among the first to demonstrate that AAT, targeting sustained attention &vigilance deficits, can produce lasting benefits. The overall goal of the current project is to measure 3 co-primary outcomes: attention, executive function and functional capacity. Evidence from our Phase I trial shows that AAT can improve attention and executive function deficits common to hemispatial neglect. At the completion of this project we will have outcomes data sufficient for submission to the FDA for clearance as a medical device indicated for cognitive enhancement in hemispatial neglect (ICD-9 Code 781.8).
The goal of this project is to revise a prototype of a computerized cognitive training program (Amplified Attention Training, AAT) for patients with hemispatial neglect completed in Phase I, and conduct a multi-site, randomized controlled trial to demonstrate efficacy. This is important because this large patient population suffers from poor prognosis and a lack of viable treatment options.
| Vleet, Thomas Van; DeGutis, Joseph; Dabit, Sawsan et al. (2014) Randomized control trial of computer-based rehabilitation of spatial neglect syndrome: the RESPONSE trial protocol. BMC Neurol 14:25 |
