We are proposing the development of a family of 3D single-slab MRI pulse sequences based on interleaved cylindrical k-space trajectories. Spin-echo-train and gradient-echo versions will be implemented on a state-of-the-art commercially available whole-body MR scanner equipped with high-performance gradients. This trajectory type features a rare combination of beneficial characteristics: high sampling efficiency, excellent off-resonance behavior, low diffusion and flow sensitivity as well as drastically reduced RF radiation exposure of the examined subject. Various optimized sequence variants will be incorporated into 3D product sequences that will benefit such diverse research areas as high-speed, high-resolution brain MRJ, contrast-enhanced MRA, high-field MRI and hyperpolarized-gas MRI, The success of each developmental step will be ensured by a stringent image quality control that ensures that the signal-to-noise and the overall image artifact load for a given set of sequence parameters is equal to or better than the competing conventional MRI pulse sequences based on rectilinear or spiral trajectories. During the commercialization phase the developed set of pulse sequences will be ported for suitable hardware and software platforms of all major MR hardware manufacturers.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
1R44RR016397-01A1
Application #
6484428
Study Section
Special Emphasis Panel (ZRG1-SSS-7 (10))
Program Officer
Swain, Amy L
Project Start
2002-04-22
Project End
2003-01-21
Budget Start
2002-04-22
Budget End
2003-01-21
Support Year
1
Fiscal Year
2002
Total Cost
$97,125
Indirect Cost
Name
Advanced MRI Technology, LLC
Department
Type
DUNS #
City
Sebastopol
State
CA
Country
United States
Zip Code
95472
Ramanna, S; Feinberg, D A (2008) Single-shot 3D GRASE with cylindrical k-space trajectories. Magn Reson Med 60:976-80