Electron Paramagnetic Resonance (EPR) Oxygen Images (EPROI) have been shown to provide quantitative localized pO2 images of animal tumors including several in syngeneic mice, and in rats, and rabbits. The parent grant has demonstrated statistically significant sharpening of the 50% tumor control dose with the addition of the information provided by the fraction of EPROI voxels less than 10 torr (HF10).
Specific aims for the current grant cycle: 1) Determining the relation between the localized oxygen information from the EPROI and pimonidazole retention, induction of hypoxia proteins and single biopsy hypoxic fraction. 2) Treatment of murine tumors to TCD50 after oxygen images and determining the predictive effectiveness of the HF10 and other EPROI tumor statistics and 3) Using the HF10 from EPROI to dose paint regions of hypoxia with IMRT to determine the impact of the EPROI on cure of mouse tumors. This work will validate quantitative oxygen imaging in optimizing radiation delivery and stimulate the development of oxygen imaging for treatment of human tumors. The funding of the Research Specialist position will enhance the technology required for the success of the parent grant through introduction of conformal beam radiation protocol and develop technology for pH and redox status guided intensity modulated radiation therapy in mouse tumors. Such support will provide sufficient time to secure funding between grant cycles.
This work develops a unique technique exploiting the knowledge of tissue oxygenation to target the most radiation resistant tumor areas with sculptured radiation beams while avoiding normal tissues. The information obtained from this technique eventually may be translated to clinics to provide better post radiation treatment quality of life. The Research Specialist will work on all aspects of radiation delivery including application of conformal radiation beams.
| Qiao, Zhiwei; Redler, Gage; Gui, Zhiguo et al. (2018) Three novel accurate pixel-driven projection methods for 2D CT and 3D EPR imaging. J Xray Sci Technol 26:83-102 |
| Kotecha, Mrignayani; Epel, Boris; Ravindran, Sriram et al. (2018) Noninvasive Absolute Electron Paramagnetic Resonance Oxygen Imaging for the Assessment of Tissue Graft Oxygenation. Tissue Eng Part C Methods 24:14-19 |
| Band, Alan; Donohue, Matthew P; Epel, Boris et al. (2018) Integration of a versatile bridge concept in a 34?GHz pulsed/CW EPR spectrometer. J Magn Reson 288:28-36 |
| Epel, Boris; Sundramoorthy, Subramanian V; Krzykawska-Serda, Martyna et al. (2017) Imaging thiol redox status in murine tumors in vivo with rapid-scan electron paramagnetic resonance. J Magn Reson 276:31-36 |
| Rinard, George A; Quine, Richard W; Buchanan, Laura A et al. (2017) Resonators for In Vivo Imaging: Practical Experience. Appl Magn Reson 48:1227-1247 |
| Sundramoorthy, Subramanian V; Epel, Boris; Halpern, Howard J (2017) A Pulse EPR 25 mT magnetometer with 10ppm resolution. Appl Magn Reson 48:805-811 |
| Nakagawa, Kouichi; Epel, Boris (2017) Investigating the Distribution of Stable Paramagnetic Species in an Apple Seed Using X-Band EPR and EPR Imaging. J Oleo Sci 66:315-319 |
| Boris, Epel; Sundramoorthy, Subramanian V; Halpern, Howard J (2017) 250 MHz passive Q-modulator for reflection resonators. Concepts Magn Reson Part B Magn Reson Eng 47B: |
| Epel, Boris; Redler, Gage; Pelizzari, Charles et al. (2016) Approaching Oxygen-Guided Intensity-Modulated Radiation Therapy. Adv Exp Med Biol 876:185-193 |
| Epel, Boris; Redler, Gage; Tormyshev, Victor et al. (2016) Towards Human Oxygen Images with Electron Paramagnetic Resonance Imaging. Adv Exp Med Biol 876:363-369 |
