Abstract

This is a Shannon Award providing partial support for research projects that fall short of the assigned institute's funding range but are in the margin of excellence. The Shannon award is intended to provide support to test the feasibility of the approach; develop further tests and refine research techniques; perform secondary analysis of available data sets; or conduct discrete projects that can demonstrate the PI's research capabilities or lend additional weight to an already meritorious application. Further scientific data for the CRISP System are unavailable at this time.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
James A. Shannon Director's Award (R55)
Project #
2R55EY004396-09
Application #
3509738
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1983-09-01
Project End
1992-03-31
Budget Start
1991-09-30
Budget End
1992-03-31
Support Year
9
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University of Texas Medical Br Galveston
Department
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555

  Publications

Sahu, Mukesh; Sharma, Rajendra; Yadav, Sushma et al. (2014) Lens specific RLIP76 transgenic mice show a phenotype similar to microphthalmia. Exp Eye Res 118:125-34
Chaudhary, Pankaj; Sharma, Rajendra; Sahu, Mukesh et al. (2013) 4-Hydroxynonenal induces G2/M phase cell cycle arrest by activation of the ataxia telangiectasia mutated and Rad3-related protein (ATR)/checkpoint kinase 1 (Chk1) signaling pathway. J Biol Chem 288:20532-46
Sharma, Rajendra; Sharma, Abha; Chaudhary, Pankaj et al. (2012) Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane. Free Radic Biol Med 52:2177-85
Vatsyayan, Rit; Lelsani, Poorna Chandra Rao; Chaudhary, Pankaj et al. (2012) The expression and function of vascular endothelial growth factor in retinal pigment epithelial (RPE) cells is regulated by 4-hydroxynonenal (HNE) and glutathione S-transferaseA4-4. Biochem Biophys Res Commun 417:346-51
Vatsyayan, Rit; Chaudhary, Pankaj; Sharma, Abha et al. (2011) Role of 4-hydroxynonenal in epidermal growth factor receptor-mediated signaling in retinal pigment epithelial cells. Exp Eye Res 92:147-54
Chaudhary, Pankaj; Sharma, Rajendra; Sharma, Abha et al. (2010) Mechanisms of 4-hydroxy-2-nonenal induced pro- and anti-apoptotic signaling. Biochemistry 49:6263-75
Sharma, Rajendra; Sharma, Abha; Chaudhary, Pankaj et al. (2010) Role of lipid peroxidation in cellular responses to D,L-sulforaphane, a promising cancer chemopreventive agent. Biochemistry 49:3191-202