The consortium Integrative Neuroscience Initiative on Alcoholism: Stress and Chronic Alcohol Interactions (a.k.a. INIAstress) is a collection of highly integrative and innovative projects and cores. The overarching goal of INIAstress is elucidating the changes in brain circuitry and mechanisms that underlie how chronic alcohol alters response to stress, which in turn can facilitate the transition from moderate/social drinking to heavy/hazardous drinking and associated problems. Through this characterization we have helped to define factors that contribute to an individual's risk for the development of alcoholism, revealed underlying mechanisms and conditions that promote excessive and harmful drinking, and forged progress towards discovering novel, more effective, and tailored treatment strategies. We continue our cross-species translational investigation and we will integrate this information to provide novel and valuable insights into diagnostic, prevention, and individualized treatment options for those suffering with alcohol use disorder (AUD) as well as co-morbidity with stress-related disorders such as post-traumatic stress disorders. Collectively, these collaborative studies directly integrate behavioral, endocrine, neural, and genetic data from animal models to humans within a scope of expertise and thematic inquiry that would not be possible using more traditional grant mechanisms. As the lead application, the Administrative Resource Core will provide scientific leadership on the consortium's main goals and serve as a centralized administrative structure to facilitate and coordinate the overall management, direction and integration of research activities within the INIAstress Consortium.

Public Health Relevance

This Administrative Resource Core of the consortium Integrative Neuroscience Initiative on Alcoholism: Stress and Chronic Alcohol Interactions (a.k.a. INIAstress) will provide oversight, direction and coordination of the 8 research projects and 3 research cores that collectively address brain circuitry and mechanisms underlying the reciprocal relationship of chronic alcohol and stress reactivity, with the overall goal of identifying new targets for effective pharmacotherapies to treat alcohol use disorders.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Resource-Related Research Projects--Cooperative Agreements (U24)
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Special Emphasis Panel (ZAA1)
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Noronha, Antonio
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Oregon Health and Science University
Other Basic Sciences
Schools of Medicine
United States
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Allen, Daicia C; Gonzales, Steven W; Grant, Kathleen A (2018) Effect of repeated abstinence on chronic ethanol self-administration in the rhesus monkey. Psychopharmacology (Berl) 235:109-120
Cuzon Carlson, Verginia C; Grant, Kathleen A; Lovinger, David M (2018) Synaptic adaptations to chronic ethanol intake in male rhesus monkey dorsal striatum depend on age of drinking onset. Neuropharmacology 131:128-142
Cervera-Juanes, R; Wilhelm, L J; Park, B et al. (2017) Alcohol-dose-dependent DNA methylation and expression in the nucleus accumbens identifies coordinated regulation of synaptic genes. Transl Psychiatry 7:e994
Cervera-Juanes, Rita; Wilhelm, Larry J; Park, Byung et al. (2017) Genome-wide analysis of the nucleus accumbens identifies DNA methylation signals differentiating low/binge from heavy alcohol drinking. Alcohol 60:103-113
Cannady, Reginald; McGonigal, Justin T; Newsom, Ryan J et al. (2017) Prefrontal Cortex KCa2 Channels Regulate mGlu5-Dependent Plasticity and Extinction of Alcohol-Seeking Behavior. J Neurosci 37:4359-4369
Siciliano, Cody A; Calipari, Erin S; Yorgason, Jordan T et al. (2016) Chronic ethanol self-administration in macaques shifts dopamine feedback inhibition to predominantly D2 receptors in nucleus accumbens core. Drug Alcohol Depend 158:159-63
Ford, Matthew M (2014) Applications of schedule-induced polydipsia in rodents for the study of an excessive ethanol intake phenotype. Alcohol 48:265-76
Piza-Palma, Carlos; Barfield, Elizabeth T; Brown, Jadeda A et al. (2014) Oral self-administration of EtOH: sex-dependent modulation by running wheel access in C57BL/6J mice. Alcohol Clin Exp Res 38:2387-95
Ford, Matthew M; Steele, Andrea M; McCracken, Aubrey D et al. (2013) The relationship between adjunctive drinking, blood ethanol concentration and plasma corticosterone across fixed-time intervals of food delivery in two inbred mouse strains. Psychoneuroendocrinology 38:2598-610
Ford, Matthew M; Davis, Natalie L; McCracken, Aubrey D et al. (2013) Contribution of NMDA glutamate and nicotinic acetylcholine receptor mechanisms in the discrimination of ethanol-nicotine mixtures. Behav Pharmacol 24:617-22

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