Abstract

This is a Shannon Award providing partial support for research projects that fall short of the assigned institute's funding range but are in the margin of excellence. The Shannon award is intended to provide support to test the feasibility of the approach; develop further tests and refine research techniques; perform secondary analysis of available data sets; or conduct discrete projects that can demonstrate the PI's research capabilities or lend additional weight to an already meritorious application. Further scientific data for the CRISP System are unavailable at this time.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
James A. Shannon Director's Award (R55)
Project #
2R55EY005856-08A1
Application #
3509740
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1988-07-16
Project End
1992-03-31
Budget Start
1991-09-30
Budget End
1992-03-31
Support Year
8
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Chang, Kun-Che; Shieh, Biehuoy; Petrash, J Mark (2016) Aldose reductase mediates retinal microglia activation. Biochem Biophys Res Commun 473:565-71
Nagaraj, Ram H; Nahomi, Rooban B; Mueller, Niklaus H et al. (2016) Therapeutic potential of ?-crystallin. Biochim Biophys Acta 1860:252-7
Chang, Kun-Che; Petrash, J Mark (2015) Aldose Reductase Mediates Transforming Growth Factor ?2 (TGF-?2)-Induced Migration and Epithelial-To-Mesenchymal Transition of Lens-Derived Epithelial Cells. Invest Ophthalmol Vis Sci 56:4198-210
Snow, Anson; Shieh, Biehuoy; Chang, Kun-Che et al. (2015) Aldose reductase expression as a risk factor for cataract. Chem Biol Interact 234:247-53
Chang, Kun-Che; Snow, Anson; LaBarbera, Daniel V et al. (2015) Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells. Chem Biol Interact 234:254-60
Li, Linfeng; Chang, Kun-Che; Zhou, Yaming et al. (2014) Design of an amide N-glycoside derivative of ?-glucogallin: a stable, potent, and specific inhibitor of aldose reductase. J Med Chem 57:71-7
Chang, Kun-Che; Ponder, Jessica; Labarbera, Daniel V et al. (2014) Aldose reductase inhibition prevents endotoxin-induced inflammatory responses in retinal microglia. Invest Ophthalmol Vis Sci 55:2853-61
Chang, Kun-Che; Laffin, Brian; Ponder, Jessica et al. (2013) Beta-glucogallin reduces the expression of lipopolysaccharide-induced inflammatory markers by inhibition of aldose reductase in murine macrophages and ocular tissues. Chem Biol Interact 202:283-7
Petrash, J Mark (2013) Aging and age-related diseases of the ocular lens and vitreous body. Invest Ophthalmol Vis Sci 54:ORSF54-9
Puppala, Muthenna; Ponder, Jessica; Suryanarayana, Palla et al. (2012) The isolation and characterization of ýý-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis. PLoS One 7:e31399

Showing the most recent 10 out of 15 publications