Funds are requested in this application to support the Rochester Training Program in Oral Science (TPOS). Additional basic and clinician-scientists will be required for society to take advantage of the rapid and dramatic advances being made in the biomedical sciences. The Center for Oral Biology?s training programs have been highly successful in recruiting, training and retaining Oral Science researchers over the past 25+ years. The University of Rochester Medical Center, including the Eastman Institute for Oral Health (EIOH), has committed substantial resources to recruit new faculty, to improve our physical plant, and to acquire new technologies; thereby, expanding the depth and breadth of training that will be necessary to excel. In support of the NIDCR Strategic Plan for 2014-2019, our goals continue to be focused on developing a well-trained, diverse workforce. The TPOS program has been designed to deliver a multidisciplinary workforce with proficiency in research design, state-of-the-art technologies and use of analytical/biostatistical techniques. We will foster in our trainees the ability to think critically about their research and that of others; and, we will use novel approaches, described in the application, to advance our trainees? ability to conduct self-assessment, facilitating their growth into independent scientists. Trainees will build their skills in presentation, publishing, and grant writing using existing Institutional faculty and resources. Finally, our Trainees will be encouraged to travel to national and international conferences, as a means of broadening their views of science, the science community, and the diversity of the human experience. Our over-arching goal is to develop in our trainees the skill sets and confidence to interact professionally with the scientific community and to undertake careers in health-related sciences. To accomplish our goals, we will recruit PhDs, and baccalaureate degree-holders pursuing a PhD, to the field of Oral Science. We will host a DSTP Program for dental students who wish to coordinate clinical studies with PhD training. This unique program partners the excellent clinical programs at the University of Puerto Rico with the PhD programs at the research-intensive University of Rochester. Our program will also include R90 research education for internationally trained DDS, PhD dual-degree holders. The components of TPOS are integrated through the Rochester Graduate Program, the clinical programs of the EIOH, and the educational resources of the Rochester Clinical and Translational Sciences Institute.

Public Health Relevance

The proposed Training Program aims to prepare scientists and dentists to become leaders in the research of oral disease and craniofacial development. The program will integrate classroom work, research in laboratories, hospitals, and dental clinics in a multidisciplinary fashion. Our long-term goal is to accelerate the pace at which effective, new treatments for diseases can be brought to the public to lessen suffering and improve lives.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Interdisciplinary Regular Research Training Award (R90)
Project #
5R90DE022529-09
Application #
9729663
Study Section
Special Emphasis Panel (ZDE1)
Program Officer
King, Lynn M
Project Start
2011-08-01
Project End
2022-06-30
Budget Start
2019-07-01
Budget End
2020-06-30
Support Year
9
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Rochester
Department
Microbiology/Immun/Virology
Type
School of Medicine & Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Maruyama, Eri O; Lin, Heng; Chiu, Shang-Yi et al. (2016) Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development. Sci Rep 6:20999
Horev, Benjamin; Klein, Marlise I; Hwang, Geelsu et al. (2015) pH-activated nanoparticles for controlled topical delivery of farnesol to disrupt oral biofilm virulence. ACS Nano 9:2390-404
Klein, Marlise I; Hwang, Geelsu; Santos, Paulo H S et al. (2015) Streptococcus mutans-derived extracellular matrix in cariogenic oral biofilms. Front Cell Infect Microbiol 5:10
Falsetta, Megan L; Klein, Marlise I; Colonne, Punsiri M et al. (2014) Symbiotic relationship between Streptococcus mutans and Candida albicans synergizes virulence of plaque biofilms in vivo. Infect Immun 82:1968-81
Liao, Sumei; Klein, Marlise I; Heim, Kyle P et al. (2014) Streptococcus mutans extracellular DNA is upregulated during growth in biofilms, actively released via membrane vesicles, and influenced by components of the protein secretion machinery. J Bacteriol 196:2355-66
Hwang, Geelsu; Klein, Marlise I; Koo, Hyun (2014) Analysis of the mechanical stability and surface detachment of mature Streptococcus mutans biofilms by applying a range of external shear forces. Biofouling 30:1079-91
Koo, H; Falsetta, M L; Klein, M I (2013) The exopolysaccharide matrix: a virulence determinant of cariogenic biofilm. J Dent Res 92:1065-73
Feng, Guoping; Klein, Marlise I; Gregoire, Stacy et al. (2013) The specific degree-of-polymerization of A-type proanthocyanidin oligomers impacts Streptococcus mutans glucan-mediated adhesion and transcriptome responses within biofilms. Biofouling 29:629-40
Klein, M I; Scott-Anne, K M; Gregoire, S et al. (2012) Molecular approaches for viable bacterial population and transcriptional analyses in a rodent model of dental caries. Mol Oral Microbiol 27:350-61
Xiao, Jin; Klein, Marlise I; Falsetta, Megan L et al. (2012) The exopolysaccharide matrix modulates the interaction between 3D architecture and virulence of a mixed-species oral biofilm. PLoS Pathog 8:e1002623

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