In response to PAR-15-101 Institutional Training for a Dental, Oral and Craniofacial Research Workforce, a T90/R90 Comprehensive Training Program in Oral Biology is proposed. Building on twenty-four years of experience with a highly productive T32 and T90/R90 Training Program at the University of Florida College of Dentistry (UFCD), the proposed program will provide extensive breadth and depth in training for basic and clinician scientists in multiple areas that are designated as high priority by the NIDCR. The scientific areas encompassed in this Comprehensive Training Program in Oral Biology include, but are not entirely limited to, Oral Infectious Diseases, Mechanistic Connections between Oral and Systemic Health, Autoimmunity, Bone Biology, Head and Neck Cancers, Salivary Gland Biology, and Neuroscience/Pain. To accomplish our goals, a team of experienced and well- supported basic and clinical researchers has been assembled to serve as mentors to provide an extensive set of training experiences in the biomedical sciences that are directly relevant to oral health and diseases. Established interdisciplinary research training programs in the UFCD and the UF College of Medicine will be utilized, with particular emphasis on the UF Health Sciences Center Interdisciplinary PhD Program in Biomedical Sciences and the recently renewed UF Clinical and Translational Science Institute (CTSI). Trainees will include i) traditional PhD students conducting oral health-related research, ii) dual-degree candidates in our DMD-PhD program, iii) degree-seeking DMD/DDS holders, iv) traditional post-doctoral PhD scientists, and v) DMD-DDS holders seeking advanced post-doctoral training to prepare them for careers in academic dentistry. Formal training in Clinical Investigation will be available to all trainees through the CTSI. Our extensive educational, scientific, and clinical resources have allowed us to develop highly integrated, yet sufficiently flexible, training options to meet the needs of a diverse group of talented trainees. Collectively, these programs will produce a cadre of highly skilled and interactive scientists who can engage in team science to generate new knowledge and translate discoveries to tangible advances in the detection, prevention, treatment and cures of diseases and abnormalities of the oral and craniofacial complex.

Public Health Relevance

There is a critical need for basic and clinical research on oral health and its relationship to overall health. If effective preventive therapies and cures for the many diseases associated with the oral and craniofacial complex are to be discovered and applied, a cadre of oral health researchers must be trained to conduct, and to maintain the highest standards for ethical and responsible implementation of, rigorous interdisciplinary scientific research. The main objective of this comprehensive training program is to produce a diverse group of oral health researchers who can work with teams of scientists to generate novel basic and clinical knowledge, translate that information to applied therapies, and rigorously evaluate the outcomes of implementation of new preventive or treatment strategies to improve human health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Interdisciplinary Regular Research Training Award (R90)
Project #
5R90DE022530-07
Application #
9306011
Study Section
Special Emphasis Panel (ZDE1)
Program Officer
King, Lynn M
Project Start
2011-07-01
Project End
2021-06-30
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
7
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Florida
Department
Dentistry
Type
Schools of Dentistry/Oral Hygn
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Huang, Xuelian; Browngardt, Christopher M; Jiang, Min et al. (2018) Diversity in Antagonistic Interactions between Commensal Oral Streptococci and Streptococcus mutans. Caries Res 52:88-101
Shaddox, L M; Mullersman, A F; Huang, H et al. (2017) Epigenetic regulation of inflammation in localized aggressive periodontitis. Clin Epigenetics 9:94
Branco-de-Almeida, L S; Cruz-Almeida, Y; Gonzalez-Marrero, Y et al. (2017) Local and Plasma Biomarker Profiles in Localized Aggressive Periodontitis. JDR Clin Trans Res 2:258-268
Miller, Karina A F S; Branco-de-Almeida, Luciana S; Wolf, Sandra et al. (2017) Long-term clinical response to treatment and maintenance of localized aggressive periodontitis: a cohort study. J Clin Periodontol 44:158-168
Huang, Xuelian; Palmer, Sara R; Ahn, Sang-Joon et al. (2016) A Highly Arginolytic Streptococcus Species That Potently Antagonizes Streptococcus mutans. Appl Environ Microbiol 82:2187-201
Huang, Xuelian; Schulte, Renee M; Burne, Robert A et al. (2015) Characterization of the arginolytic microflora provides insights into pH homeostasis in human oral biofilms. Caries Res 49:165-76
Nascimento, M M; Liu, Y; Kalra, R et al. (2013) Oral arginine metabolism may decrease the risk for dental caries in children. J Dent Res 92:604-8
Burne, R A; Zeng, L; Ahn, S J et al. (2012) Progress dissecting the oral microbiome in caries and health. Adv Dent Res 24:77-80
Liu, Ya-Ling; Nascimento, Marcelle; Burne, Robert A (2012) Progress toward understanding the contribution of alkali generation in dental biofilms to inhibition of dental caries. Int J Oral Sci 4:135-40
Liu, Yaling; Burne, Robert A (2011) The major autolysin of Streptococcus gordonii is subject to complex regulation and modulates stress tolerance, biofilm formation, and extracellular-DNA release. J Bacteriol 193:2826-37