This application addresses broad Challenge Area (03) Biomarker Discovery and Validation, and specific Challenge Topic, 03-MH-101 Biomarkers in mental disorders. The variability of treatment outcome in PTSD, the high risk of relapse and the fact that only a subset of trauma victims develop PTSD are unsolved aspects of the illness. Yet at the current time there are no tests or markers that can help guide treatment decisions about which treatment should be administered to a particular patient, how long the person should be treated or whether trauma victims at high risk can be identified early, prior to the onset of illness. We have therefore developed a model of emotional circuitry abnormalities in PTSD. With funding of the current application we propose to validate these abnormalities as biomarkers in PTSD that can be further developed to guide treatment decisions. Post Traumatic Stress Disorder (PTSD) is a common, severe psychiatric problem that occurs in some people following a traumatic event. Treatment outcomes are variable and incomplete. Relapse is common. Brain biomarkers of abnormal emotional circuitry could provide evidence of insufficient treatment and high risk for relapse. Biomarkers could identify subgroups of patients who are better suited to a particular treatment.
Post Traumatic Stress Disorder (PTSD) is a common, severe psychiatric problem that occurs in some people following a traumatic event. Treatment outcomes are variable and incomplete. Relapse is common. Brain biomarkers of abnormal emotional circuitry could provide evidence of insufficient treatment and high risk for relapse. Biomarkers could identify subgroups of patients who are better suited to a particular treatment.
|Yang, Zhen; Oathes, Desmond J; Linn, Kristin A et al. (2018) Cognitive Behavioral Therapy Is Associated With Enhanced Cognitive Control Network Activity in Major Depression and Posttraumatic Stress Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging 3:311-319|
|Shou, Haochang; Yang, Zhen; Satterthwaite, Theodore D et al. (2017) Cognitive behavioral therapy increases amygdala connectivity with the cognitive control network in both MDD and PTSD. Neuroimage Clin 14:464-470|
|Brown, Wilson J; Wojtalik, Jessica A; Dewey, Daniel et al. (2016) Affect and neural activity in women with PTSD during a task of emotional interference. J Affect Disord 204:9-15|
|Buchholz, Katherine R; Bruce, Steven E; Koucky, Ellen M et al. (2016) Neural Correlates of Trait Rumination During an Emotion Interference Task in Women With PTSD. J Trauma Stress 29:317-24|
|Satterthwaite, T D; Cook, P A; Bruce, S E et al. (2016) Dimensional depression severity in women with major depression and post-traumatic stress disorder correlates with fronto-amygdalar hypoconnectivty. Mol Psychiatry 21:894-902|
|Hu, Emily; Koucky, Ellen M; Brown, Wilson J et al. (2014) The Role of Rumination in Elevating Perceived Stress in Posttraumatic Stress Disorder. J Interpers Violence 29:1953-62|
|Bruce, Steven E; Buchholz, Katherine R; Brown, Wilson J et al. (2012) Altered emotional interference processing in the amygdala and insula in women with Post-Traumatic Stress Disorder. Neuroimage Clin 2:43-9|
|Sheline, Yvette I (2011) Depression and the hippocampus: cause or effect? Biol Psychiatry 70:308-9|