A primary objective of the 2012 National Alzheimer's Plan Act was to decrease racial disparities of dementia. While it is known that certain ethnoracial groups such as Blacks have higher rates of dementia, reasons for disparities are unknown. The NIH State of the Science on Preventing Cognitive Decline recommended a life course approach to identifying modifiable risk and protective factors. Whether early life factors contribute to ethnic disparities in dementia and cognitive decline and how these variables relate to brain changes that may mediate disparities is not well understood. Further, effects of risk and protective factors may vary across ethnoracial groups. Most of what is known about risk and protective factors and brain mechanisms for dementia is from studies of non-Hispanic whites. We propose an unprecedented lifecourse study of disparities in late life cognitive decline and dementia using a large multi-ethnoracial sample of current Kaiser Permanente health system members who participated in the Multiphasic Health Study (MHS) extending from 1964-1991. MHS data, joined with electronic medical records from 1996-present, provide up to 50 years of comprehensive, prospectively collected data. Eighteen hundred (450 Black, 450 Hispanic, 450 White, 450 Asian) MHS participants aged 65+ will receive cognitive and clinical evaluations at 3 time points to rigorously characterize prevalence and incidence of dementia and measure cognitive decline using well-validated tests for ethnoracially diverse older adults. Structural MRI and Amyloid PET will be obtained on a random sub sample of 400 non-demented individuals to characterize cerebral amyloid burden, vascular lesions, and neuronal injury (atrophy). Our objectives are to delineate why there are racial/ethnic disparities in dementia and how life course risk and protective factors and brain mechanisms differ across ethnoracial groups. We will do so with three Specific Aims: 1) Evaluate ethnoracial differences in dementia incidence and cognitive decline, 2) Evaluate how early life experience, life course health, and genetics influence ethnoracial differences in cognitive decline and dementia, 3) Characterize paths by which ethnicity/race and cumulative vascular risk influence brain status (amyloid, vascular brain injury, atrophy) and cognitive decline.
In 2012 President Obama signed the National Alzheimer's Plan Act with a primary objective to decrease racial disparities of dementia. While it is known that certain ethnoracial groups such as Blacks have higher rates of dementia, reasons for these disparities are unknown. We propose an unprecedented lifecourse study of ethnic disparities in late life cognitive outcomes using a large multi-ethnic sample with over 5 decades of prospectively collected life history and health data. Our overall objectives are to delineate why there are racial/ethnic disparities in dementia and how risk and protective factors and brain mechanisms differ across ethnoracial groups.
| Gilsanz, Paola; Mayeda, Elizabeth Rose; Glymour, M Maria et al. (2018) Birth in High Infant Mortality States and Dementia Risk in a Cohort of Elderly African American and White Health Care Members. Alzheimer Dis Assoc Disord : |
| Flatt, Jason D; Gilsanz, Paola; Quesenberry Jr, Charles P et al. (2018) Post-traumatic stress disorder and risk of dementia among members of a health care delivery system. Alzheimers Dement 14:28-34 |
| Mayeda, Elizabeth Rose; Filshtein, Teresa J; Tripodis, Yorghos et al. (2018) Does selective survival before study enrolment attenuate estimated effects of education on rate of cognitive decline in older adults? A simulation approach for quantifying survival bias in life course epidemiology. Int J Epidemiol 47:1507-1517 |
| Gilsanz, Paola; Mayeda, Elizabeth Rose; Flatt, Jason et al. (2018) Early Midlife Pulmonary Function and Dementia Risk. Alzheimer Dis Assoc Disord 32:270-275 |
| Mayeda, Elizabeth Rose; Banack, Hailey R; Bibbins-Domingo, Kirsten et al. (2018) Can Survival Bias Explain the Age Attenuation of Racial Inequalities in Stroke Incidence?: A Simulation Study. Epidemiology 29:525-532 |
| Mayeda, Elizabeth R; Glymour, M Maria; Quesenberry Jr, Charles P et al. (2017) Heterogeneity in 14-year Dementia Incidence Between Asian American Subgroups. Alzheimer Dis Assoc Disord 31:181-186 |
| Mayeda, Elizabeth R; Glymour, M Maria; Quesenberry, Charles P et al. (2017) Survival after dementia diagnosis in five racial/ethnic groups. Alzheimers Dement 13:761-769 |
