This project is to develop and apply strategies for conducting whole genome association (WGA) studies of multiple neurobehavioral phenotypes. It is now feasible to conduct well powered WGA studies;however, progress in understanding the biological basis of neuropsyehiatric diseases will be slow if such studies are conducted one phenotype at a time. The Northern Finland Birth Cohort of 1966 (NFBC1966) offers a rich phenotype database from a genetically homogeneous population and is therefore ideal for initiation of a phenomic approach: the joint analysis of whole genome genotypes with an extensive set of phenotypes. Almost 2000 members of NFBC1966 will be genotyped using a densely spaced array of single nucleotide polymorphisms (SNPs), providing excellent power to detect associations to these phenotypes, at a genomewide level of significance, even for genetic variants of relatively modest effect. Genotyping the remaining 3000 members of NFBC1966 using the significant SNPs will permit replication of these associations. To implement a phenomic approach, the investigative team will develop and apply methodology that enables efficient analysis of the phenotype-genotype data. Data mining will identify novel composite phenotypes. A variety of statistical methods will be applied to the problem of analyzing large numbers of phenotypes. In particular, these methods will use genotype data to determine whether novel phenotypes have a genetic basis, will analyze the joint contributions of multiple genomic locations'to phenotypic variation, and will explore the use of genotypic similarity between subjects as a means to genetically map large numbers of phenotypes. This methodology will also be used to analyze the WGA data from a Californian cohort to be collected by the Consortium for Neuropsyehiatric Phenomics.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Linked Research project Grant (RL1)
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Special Emphasis Panel (ZRR1-SRC (99))
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Yao, Yin Y
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University of California Los Angeles
Schools of Medicine
Los Angeles
United States
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Aslibekyan, Stella; Agha, Golareh; Colicino, Elena et al. (2018) Association of Methylation Signals With Incident Coronary Heart Disease in an Epigenome-Wide Assessment of Circulating Tumor Necrosis Factor ?. JAMA Cardiol 3:463-472
Liuhanen, Johanna; Suvisaari, Jaana; Kajantie, Eero et al. (2018) Interaction between compound genetic risk for schizophrenia and high birth weight contributes to social anhedonia and schizophrenia in women. Psychiatry Res 259:148-153
Teslovich, Tanya M; Kim, Daniel Seung; Yin, Xianyong et al. (2018) Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study. Hum Mol Genet 27:1664-1674
Beckmeyer-Borowko, Anna; Imboden, Medea; Rezwan, Faisal I et al. (2018) SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults: a meta-analysis of ALEC population-based cohorts. Respir Res 19:156
Orban, Pierre; Dansereau, Christian; Desbois, Laurence et al. (2018) Multisite generalizability of schizophrenia diagnosis classification based on functional brain connectivity. Schizophr Res 192:167-171
Ortega-Alonso, Alfredo; Ekelund, Jesper; Sarin, Antti-Pekka et al. (2017) Genome-Wide Association Study of Psychosis Proneness in the Finnish Population. Schizophr Bull 43:1304-1314
Graversen, L; Howe, L D; Sørensen, T I A et al. (2017) Body mass index trajectories from 2 to 18?years - exploring differences between European cohorts. Pediatr Obes 12:102-109
Poobalasingam, Thanushiyan; Yates, Laura L; Walker, Simone A et al. (2017) Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair. Dis Model Mech 10:409-423
Kraja, Aldi T; Cook, James P; Warren, Helen R et al. (2017) New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475?000 Individuals. Circ Cardiovasc Genet 10:
Gill, Dipender; Sheehan, Nuala A; Wielscher, Matthias et al. (2017) Age at menarche and lung function: a Mendelian randomization study. Eur J Epidemiol 32:701-710

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