The analysis of neuroanatomical information is a labor-intensive process which is usually limited by the stamina of the investigators. Limitations on the latter may lead to either a decrease in the quantity of tissue analyzed or a degradation in the quality of the analysis, or to both. It is now possible using computer-based techniques to increase productivity, in the number and quality of neuroanatomical images generated. Furthermore, the integration of such images into three-dimensional reconstructions which can be readily manipulated to yield the clearest possible representation of findings is a new capability made available by computer technology. The present proposal is to apply a powerful neuroanatomical image handling system in the context of four ongoing research efforts; 1. a study of the integration of central pain, analgesic, and autonomic mechanisms in the mammalian brain (Drs. Koh and Kream); 2. a study of mechanisms of central opioid analgesia, using an animal model of stress analgesia (Drs. Thompson, Koh, Miczek, and Shuster); 3. a study of hypothalamic structure and function, including mechanisms of ovulatory control, and the generation of circadian rhythms in the human hypothalamus (Drs. Stopa and King), and 4. a study of the organization of olfactory processing in the amphibian brain, using 2-deoxyglucose autoradiographic and intracellular staining techniques (Drs. Hamilton and Kauer). The following discussion will describe a new image analysis system which has been designed for use in high-resolution neuroanatomical work, and present the particular merits of the system as applied to each of the four project areas listed above.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Unknown (S03)
Project #
2S03RR003442-06
Application #
3512595
Study Section
Special Emphasis Panel (NSS)
Project Start
1986-03-01
Project End
1992-02-29
Budget Start
1991-03-01
Budget End
1992-02-29
Support Year
6
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Nationwide Children's Hospital
Department
Type
DUNS #
City
Columbus
State
OH
Country
United States
Zip Code
43205
Dietrich, A M; James, C D; King, D R et al. (1994) Head trauma in children with congenital coagulation disorders. J Pediatr Surg 29:28-32