We propose the acquisition of a high-field NMR spectrometer. The spectrometer is necessary to provide structural information (e.g., from relaxation and two dimensional NMR experiments) about DNA fragments, proteins, and drugs in solution. The information derived from the NMR experiments will be used in conjunction with distance geometry calculations and computer graphics to generate molecular structures in solution in greater detail than presently exists.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Unknown (S03)
Project #
2S03RR003479-05
Application #
3512815
Study Section
Special Emphasis Panel (NSS)
Project Start
1988-03-01
Project End
1993-02-28
Budget Start
1992-03-06
Budget End
1993-02-28
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
017730458
City
Cleveland
State
OH
Country
United States
Zip Code
44195