In this project we propose to synthesize new potential medicinal agents which are analogs or derivatives of two different types of compounds. One model compound is a 2,3-diaryl-3-chloropropenal (NCI-618121) that has been shown to be active against HIV and may be active against breast cancer. The other is 4-(3,4-dimethoxy-benzylidene)homophthalimide which is active in the NCI screen against cancer.
Our aim i s to prepare derivatives of NCI-618121 that will retain anti-viral activity and possess greater bioavailability; we shall also synthesize analogs of the active homophthalimide compound to explore the scope of activity in this new structural type. Two undergraduate and two graduate students will be selected to work on this project.

Project Start
1997-06-01
Project End
1998-05-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
27
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Fisk University
Department
Type
DUNS #
052144326
City
Nashville
State
TN
Country
United States
Zip Code
37208