The proposed work consists of project I and II. Project I seeks to understand the structural and functional relationship of the multipartite viral RNAs. Our discovery of internal poly-A of about 25 nucleotides has shed new light of the """"""""silent cistron"""""""" in a dicistronic setting, and the production of the subgenomic coat protein cistron from RNA3. Further research is in progress to determine the universality of internal poly-A in viral RNA messengers. Project II deals with synthesis of some mod@fied purines nucleosides and nucleotides. The objective is to relate structural changes to biological function. Work is still in progress in this area.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
5S06RR008050-14
Application #
3513838
Study Section
General Research Support Program Advisory Committee (GRS)
Project Start
1977-06-01
Project End
1986-12-31
Budget Start
1985-04-01
Budget End
1985-12-31
Support Year
14
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Bishop College
Department
Type
Schools of Arts and Sciences
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75241