Synthetic methods and purification techniques have been developed for preparation of porphyrins containing one, two, three and four reactive functional groups (e.g., phenolic -OH, -NH2 and -NO2) on phenyl rings. Three porphyrins, containing alkylating groups, have been prepared for studying their antitumor effects, with and without radiation in, experimental animals and cell culture. A redox system has been developed for the iron (III) tetraphenylporphyrins. Studies have been carried out in several reducting solvents that also served as coordinating ligands. A study of the binding of carbon monoxide and nitric oxide ligands with oxidized and reduced forms of iron tetraphenylporphyrins have been completed.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
5S06RR008060-16
Application #
3513852
Study Section
General Research Support Program Advisory Committee (GRS)
Project Start
1977-06-01
Project End
1987-05-31
Budget Start
1986-06-01
Budget End
1987-05-31
Support Year
16
Fiscal Year
1986
Total Cost
Indirect Cost
Name
South Carolina State University
Department
Type
Schools of Arts and Sciences
DUNS #
626143457
City
Orangeburg
State
SC
Country
United States
Zip Code
29115
Byrnes, R W; Fiel, R J; Datta-Gupta, N (1988) DNA strand scission by iron complexes of meso-tetra(N-methylpyridyl)porphines. Chem Biol Interact 67:225-41