An objective of this project is to prepare a series of isoquinoline type alkaloids by new synthetic routes and to obtain information about the biological properties of the target compounds and significant intermediates. The biological testing is done by arrangements with other established laboratories. The present work has involved the confirmation of structure of reductively coupling quinoline derivatives, the synthesis of homophthalimide derivatives that have shown marked activity affecting plant growth, and the preparation of a key intermediate for the synthesis of the cytotoxic alkaloid, sesbanine. Other work-in progress includes synthesis of pavine, aporphine, dibenzopyrrocoline and benzo(c) phenathridine alkaloids.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
2S06RR008062-17
Application #
3513859
Study Section
General Research Support Program Advisory Committee (GRS)
Project Start
1977-06-01
Project End
1991-05-31
Budget Start
1987-06-01
Budget End
1988-05-31
Support Year
17
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Fisk University
Department
Type
Schools of Arts and Sciences
DUNS #
052144326
City
Nashville
State
TN
Country
United States
Zip Code
37208
Sambandam, T; Gunasekaran, M (1993) Purification and properties of calmodulin from Phymatotrichum omnivorum. Microbios 73:61-74
Ike, J; Sangan, P; Gunasekaran, M (1992) Purification and properties of lactate dehydrogenase from Nocardia asteroides. Microbios 69:119-27
Sambandam, T; Gunasekaran, M (1987) Purification and properties of phosphorylase from Phymatotrichum omnivorum. Arch Biochem Biophys 254:579-85
Gunasekaran, M; Sambandam, T (1986) Rapid diagnostic methods for aspergillosis. Zentralbl Bakteriol Mikrobiol Hyg A 261:523-8