Today it is possible, using techniques developed during the past decade, to study gene products at the molecular level and to analyze relationships between genes. The first year of the project will be spent giving our participating students exposure to the techniques of protein sequence searches, comparisons and alignments using databases holding the more than 7,500 protein sequences now available. Students will learn current methods of search, comparison and alignment of protein sequences. They will be introduced to other methods used to solve problems related to distinguishing between the sense and nonsense contained in eukaryotic chromosomes. A primary goal of the project will be to introduce our students to views on molecular evolution as regards sequence comparisons. The methods will make use of our campus computer facilities, the San Diego Supercomputer Center and desktop personal computers. The students will explore techniques to take advantage of current color graphics technology for the illustration of sequence similarities vividly and more rapidly than is now done with tables of numeric indices.
| Taba, A; Quezada, B H; Robles, L J (1989) Microscopic and biochemical characterization of lectin binding sites in the cephalopod retina. J Comp Neurol 283:559-67 |
| Chi, L W; Andreus, J; Yates, R A et al. (1988) Worm burden and lymphocyte response in mice immunized with N-methyl-N'-nitro-N-nitrosoguanidine attenuated cercariae of schistosoma japonicum. Chin Med J (Engl) 101:181-6 |
| Robles, L J; Watanabe, A; Kremer, N E et al. (1987) Immunocytochemical localization of photopigments in cephalopod retinae. J Neurocytol 16:403-15 |
| Breneman, J W; Robles, L J; Bok, D (1986) Light-activated retinoid transport in cephalopod photoreceptors. Exp Eye Res 42:645-58 |
| Robles, L J; Breneman, J W; Anderson, E O et al. (1986) Immunocytochemical localization of a rhodopsin-like protein in the lipochondria in photosensitive neurons of Aplysia californica. Cell Tissue Res 244:115-20 |
