This proposal involves the synthesis of several new analogs of methotrexate, an anti-neoplastic agent. On the basis of prior metabolic studies, these analogs (7-substituted derivatives) are predicted to be less toxic than methotrexate at a high dose regimen. The research will be carried out primarily by the principal investigator and junior college students who have demonstrated a potential or capability for biomedically related fields. Synthetic schemes based on procedures that have already been reasonably developed will be utilized. At the completion of the synthesis, analogs will be submitted for biological activity studies.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
5S06RR008177-08
Application #
3514135
Study Section
General Research Support Program Advisory Committee (GRS)
Project Start
1980-03-01
Project End
1990-02-28
Budget Start
1987-03-01
Budget End
1988-02-29
Support Year
8
Fiscal Year
1987
Total Cost
Indirect Cost
Name
East Los Angeles College
Department
Type
Other Specialized Schools
DUNS #
City
Monterey Park
State
CA
Country
United States
Zip Code
91754