Oregon Research Institute is a non-profit research organization with 36 behavioral scientists. The Institute supports a central computing facility for data processing and statistical analysis of research project data (95% of use by PHS projects). The current VAX 8200 computing system was acquired in 1986. Since then, the number and size of grants at the Institute has grown significantly (from $1.6 million indirect to $3.5 million). This growth has resulted in subsequent increases in the size, number, and complexity of analytic tasks carried out by the projects, and a dramatic expansion in the demand for data processing and statistical analysis. For example, in 1986 there were 10 terminal ports; now there are 75 ports. Unfortunately, the current computing system has proven inadequate for this expanded task, and it has become necessary to limit the number of concurrent users to 20. Research staff are frequently unable to gain access to the computer, because it has been necessary to limit the number of concurrent users. User demands on the resource have degraded the responsiveness of the system such that analytic tasks frequently must be completed on an overnight basis. This situation has hampered the completion of data processing and analyses that are central to the dissemination and publication of project results. Consequently, this proposal requests that the current facility be upgraded to meet the new demand.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Grants (S07)
Project #
2S07RR005903-07
Application #
3517099
Study Section
Special Emphasis Panel (NSS)
Project Start
1984-04-01
Project End
1991-03-31
Budget Start
1990-04-01
Budget End
1991-03-31
Support Year
7
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Center for Molecular Medicine/Immunology
Department
Type
DUNS #
City
Belleville
State
NJ
Country
United States
Zip Code
07950
Goldenberg, D M (1994) New developments in monoclonal antibodies for cancer detection and therapy. CA Cancer J Clin 44:43-64
Goldenberg, D M (1993) Monoclonal antibodies in cancer detection and therapy. Am J Med 94:297-312
Blumenthal, R D; Sharkey, R M; Haywood, L et al. (1992) Targeted therapy of athymic mice bearing GW-39 human colonic cancer micrometastases with 131I-labeled monoclonal antibodies. Cancer Res 52:6036-44
Blumenthal, R D; Kashi, R; Stephens, R et al. (1991) Improved radioimmunotherapy of colorectal cancer xenografts using antibody mixtures against carcinoembryonic antigen and colon-specific antigen-p. Cancer Immunol Immunother 32:303-10
Tanaka, A; Salem, M; Eckroade, R J et al. (1990) Characterization of avian retroviruses carrying activated transforming human c-src genes and of steps involved in expression of activated src-PKases in vitro. Oncogene Res 5:305-22
Blumenthal, R D; Sharkey, R M; Goldenberg, D M (1990) Experimental model systems for antibody targeting and radioimmunodetection. Cancer Treat Res 51:29-52
Stein, R; Chen, S; Sharkey, R M et al. (1990) Murine monoclonal antibodies raised against human non-small cell carcinoma of the lung: specificity and tumor targeting. Cancer Res 50:1330-6
Ong, G L; Mattes, M J (1989) Penetration and binding of antibodies in experimental human solid tumors grown in mice. Cancer Res 49:4264-73
Stein, R; Goldenberg, D M (1988) A murine monoclonal antibody raised against human non-small cell carcinoma of the lung. Hybridoma 7:555-67