We propose the replacement of a 12-year-old GE (Signa LX) MRI console with a state-of-the-art Varian/Agilent console to support magnetic resonance microscopy for scientists throughout the world. Coupled to an existing 9.4T magnet and a new generation of cryogenic rf probe, this truly unique imaging system will support spatial resolution at the diffusion limit (<10 micrometers). A novel diffusion tensor imaging strategy will provide routine imaging with isotropic spatial resolution <20 micrometers. This resource will support the work of 18 NIH-funded investigators with 27 NIH grants. The system will allow us to increase the throughput for routine magnetic resonance microscopy by more than 3 times;increase the spatial resolution over limited fields by nearly 10 times;and reduce the scan time for diffusion tensor microscopy by at least 4 times.

Public Health Relevance

Sequencing of the human genome has opened an entirely new era of molecular medicine, and one of the most critical issues faced is connecting the vast information in the sequenced human genome to the physical expression-the phenotype. Mouse models are one a critical vehicles to this understanding. Magnetic resonance histology will be used to understand changes in brain morphology of a number of the most critical models, helping connect genotype to phenotype.

National Institute of Health (NIH)
Office of The Director, National Institutes of Health (OD)
Biomedical Research Support Shared Instrumentation Grants (S10)
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Special Emphasis Panel (ZRG1-SBIB-W (30))
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Levy, Abraham
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Duke University
Schools of Medicine
United States
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Calabrese, Evan; Adil, Syed M; Cofer, Gary et al. (2018) Postmortem diffusion MRI of the entire human spinal cord at microscopic resolution. Neuroimage Clin 18:963-971
Badea, Alexandra; Kamnaksh, Alaa; Anderson, Robert J et al. (2018) Repeated mild blast exposure in young adult rats results in dynamic and persistent microstructural changes in the brain. Neuroimage Clin 18:60-73
Dibb, Russell; Liu, Chunlei (2017) Joint eigenvector estimation from mutually anisotropic tensors improves susceptibility tensor imaging of the brain, kidney, and heart. Magn Reson Med 77:2331-2346
Vetreno, Ryan P; Yaxley, Richard; Paniagua, Beatriz et al. (2017) Adult rat cortical thickness changes across age and following adolescent intermittent ethanol treatment. Addict Biol 22:712-723
GraƱa, Gilberto David; Hutson, Kendall A; Badea, Alexandra et al. (2017) The organization of frequency and binaural cues in the gerbil inferior colliculus. J Comp Neurol 525:2050-2074
Wei, Hongjiang; Gibbs, Eric; Zhao, Peida et al. (2017) Susceptibility tensor imaging and tractography of collagen fibrils in the articular cartilage. Magn Reson Med 78:1683-1690
Dibb, Russell; Xie, Luke; Wei, Hongjiang et al. (2017) Magnetic susceptibility anisotropy outside the central nervous system. NMR Biomed 30:
Rangarajan, Janaki Raman; Vande Velde, Greetje; van Gent, Friso et al. (2016) Image-based in vivo assessment of targeting accuracy of stereotactic brain surgery in experimental rodent models. Sci Rep 6:38058
Xie, Luke; Layton, Anita T; Wang, Nian et al. (2016) Dynamic contrast-enhanced quantitative susceptibility mapping with ultrashort echo time MRI for evaluating renal function. Am J Physiol Renal Physiol 310:F174-82
Xie, Luke; Bennett, Kevin M; Liu, Chunlei et al. (2016) MRI tools for assessment of microstructure and nephron function of the kidney. Am J Physiol Renal Physiol 311:F1109-F1124

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