Abstract

Partial support is requested to upgrade NMR spectrometers located in the National Magnetic Resonance Facility at Madison (NMRFAM). The spectrometer systems currently have AM consoles (circa 1985 technology). These are to be replaced by consoles that represent the state-of-the-art. The present consoles make it difficult or impossible to carry out newer multinuclear, multidimensional NMR experiments. The upgrades will include new probes with improved temperature uniformity across the sample, larger probes for dealing with less-soluble samples or for obtaining more accurate cross-relaxation data, and field gradient probes for optimal solvent suppression. The upgrades will benefit a large number of ongoing projects (several supported by the NIH) and will increase the research effectiveness of the NIH-supported facility as a whole. Each of the major user groups has considerable prior NMR expertise or is collaborating with staff members of NMRFAM. The instruments will be housed in the NMR facility and will be maintained by the staff of the NMR facility who are supported in part by University funds. NMRFAM staff members will train users to operate the upgraded equipment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10RR008438-01
Application #
3522073
Study Section
Special Emphasis Panel (SSS (S2))
Project Start
1993-08-01
Project End
1994-07-31
Budget Start
1993-08-01
Budget End
1994-07-31
Support Year
1
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Type
Schools of Earth Sciences/Natur
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Gandhi, N N; Cobra, P F; Steele, J L et al. (2018) Lactobacillus demonstrate thiol-independent metabolism of methylglyoxal: Implications toward browning prevention in Parmesan cheese. J Dairy Sci 101:968-978
Travers, Timothy; López, Cesar A; Van, Que N et al. (2018) Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain. Sci Rep 8:8461
Thomas, Nathan E; Wu, Chao; Morrison, Emma A et al. (2018) The C terminus of the bacterial multidrug transporter EmrE couples drug binding to proton release. J Biol Chem 293:19137-19147
Yang, Yifang; Cornilescu, Gabriel; Tal-Gan, Yftah (2018) Structural Characterization of Competence-Stimulating Peptide Analogues Reveals Key Features for ComD1 and ComD2 Receptor Binding in Streptococcus pneumoniae. Biochemistry 57:5359-5369
Wijayatunga, Nadeeja N; Sams, Valerie G; Dawson, John A et al. (2018) Roux-en-Y gastric bypass surgery alters serum metabolites and fatty acids in patients with morbid obesity. Diabetes Metab Res Rev 34:e3045
Assadi-Porter, Fariba M; Reiland, Hannah; Sabatini, Martina et al. (2018) Metabolic Reprogramming by 3-Iodothyronamine (T1AM): A New Perspective to Reverse Obesity through Co-Regulation of Sirtuin 4 and 6 Expression. Int J Mol Sci 19:
Wales, Jessica A; Chen, Cheng-Yu; Breci, Linda et al. (2018) Discovery of stimulator binding to a conserved pocket in the heme domain of soluble guanylyl cyclase. J Biol Chem 293:1850-1864
Schilke, Brenda A; Ciesielski, Szymon J; Ziegelhoffer, Thomas et al. (2017) Broadening the functionality of a J-protein/Hsp70 molecular chaperone system. PLoS Genet 13:e1007084
Adnani, Navid; Chevrette, Marc G; Adibhatla, Srikar N et al. (2017) Coculture of Marine Invertebrate-Associated Bacteria and Interdisciplinary Technologies Enable Biosynthesis and Discovery of a New Antibiotic, Keyicin. ACS Chem Biol 12:3093-3102
Vasquez, Joseph K; Tal-Gan, Yftah; Cornilescu, Gabriel et al. (2017) Simplified AIP-II Peptidomimetics Are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors. Chembiochem 18:413-423

Showing the most recent 10 out of 203 publications