Abstract

? This proposal requests a 9.4T Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS or FTMS) for applications in structural biology, signal transduction, and biological discovery. There is local expertise in the use of FT-ICR-MS, and a long track record of the PI and this group in effective use and tong term support of shared resources and instrumentation. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10RR019891-01
Application #
6803715
Study Section
Special Emphasis Panel (ZRG1-BPC-D (30))
Program Officer
Tingle, Marjorie
Project Start
2004-07-01
Project End
2007-06-30
Budget Start
2004-07-01
Budget End
2007-06-30
Support Year
1
Fiscal Year
2004
Total Cost
$1,666,783
Indirect Cost

  Institution

Name
Albert Einstein College of Medicine
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461

  Publications

Albuquerque, Patrícia; Nicola, André M; Nieves, Edward et al. (2013) Quorum sensing-mediated, cell density-dependent regulation of growth and virulence in Cryptococcus neoformans. MBio 5:e00986-13
Chen, Jerri; Angeletti, Ruth; McDonald, Thomas V et al. (2012) Binding interface of cardiac potassium channel proteins identified by hydrogen deuterium exchange of synthetic peptides. Anal Bioanal Chem 403:1303-9
Wang, Shanzhi; Lim, Jihyeon; Thomas, Keisha et al. (2012) A complex of methylthioadenosine/S-adenosylhomocysteine nucleosidase, transition state analogue, and nucleophilic water identified by mass spectrometry. J Am Chem Soc 134:1468-70
Berezniuk, Iryna; Vu, Hang T; Lyons, Peter J et al. (2012) Cytosolic carboxypeptidase 1 is involved in processing ?- and ?-tubulin. J Biol Chem 287:6503-17
Xiao, Hui; Wang, Hui; Zhang, Xuechun et al. (2012) Structural evidence for cooperative microtubule stabilization by Taxol and the endogenous dynamics regulator MAP4. ACS Chem Biol 7:744-52
Xu, Hua; Hazra, Saugata; Blanchard, John S (2012) NXL104 irreversibly inhibits the ?-lactamase from Mycobacterium tuberculosis. Biochemistry 51:4551-7
Zhang, Qi; Xiao, Hui; Chai, Sergio C et al. (2011) Hydrophilic residues are crucial for ribosomal protein L11 (RPL11) interaction with zinc finger domain of MDM2 and p53 protein activation. J Biol Chem 286:38264-74
Khrapunovich-Baine, Marina; Menon, Vilas; Yang, Chia-Ping Huang et al. (2011) Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation. J Biol Chem 286:11765-78
Stitt, Barbara L; Xiao, Hui (2010) Conformation changes in E. coli Rho monitored by hydrogen/deuterium exchange and mass spectrometry: response to ligand binding. J Mol Biol 402:813-24
Miller, Leah M; Xiao, Hui; Burd, Berta et al. (2010) Methods in tubulin proteomics. Methods Cell Biol 95:105-26

Showing the most recent 10 out of 14 publications