The University of Maryland, Baltimore currently has 18 NIH funded research projects that could greatly benefit from the availability of a shared high-field animal imaging magnetic resonance system. The projects cover a wide array of high impact, cutting edge biomedical research including topics such as, brain development and disease processes through diffusion tensor imaging, understanding brain metabolism involved in white matter disease, understanding progression of breast and prostate cancer and studying the efficacy of therapeutic agents, the pathogenic mechanisms of human herpesvirus, tumorigenesis, the progression of neurodegenerative events and studying the long and short term consequences of pharmacological treatment, the neuronal mechanisms of pain, cardiac dynamics, metabolic and development aspects of mental retardation, development of drug delivery agents for effective treatment of cancer, and many other such projects that are state-of-the-art and push the envelope of our scientific knowledge. The availability of a shared 7 Tesla animal MRI would allow investigators to probe into basic biological processes, understand the progression of disease, and follow the effects of novel pharmacological interventions through the use of multi-nuclear spectroscopy and imaging. The purchase of a 7.0 Tesla animal imaging system will be an important component to our existing shared resources on campus and will complement the high resolution NMR spectrometers that are used primarily for studying biological structures. This imaging resource will be located in specially designed space, in close proximity to the animal holding area and right next to two animal surgical suites. The Schools of Medicine, Pharmacy, and Dentistry, the Greenebaum Research Center, and the University of Maryland Biotechnology Institute join together in this shared instrument application. Institutional commitment for supporting the expenses and responsibilities for its operations will also be shared by the different schools and institutes of this campus. The number and quality of biomedical research projects performed at the University of Maryland Baltimore campus has reached a level that will guarantee a continued and pressing need to a high-field animal imaging system.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10RR019935-01
Application #
6803785
Study Section
Special Emphasis Panel (ZRG1-SRB (30))
Program Officer
Tingle, Marjorie
Project Start
2005-05-01
Project End
2008-04-30
Budget Start
2005-05-01
Budget End
2008-04-30
Support Year
1
Fiscal Year
2005
Total Cost
$1,978,000
Indirect Cost
Name
University of Maryland Baltimore
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201
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Xu, Su; Waddell, Jaylyn; Zhu, Wenjun et al. (2015) In vivo longitudinal proton magnetic resonance spectroscopy on neonatal hypoxic-ischemic rat brain injury: Neuroprotective effects of acetyl-L-carnitine. Magn Reson Med 74:1530-42
Mullins, Roger J; Xu, Su; Pereira, Edna F R et al. (2015) Prenatal exposure of guinea pigs to the organophosphorus pesticide chlorpyrifos disrupts the structural and functional integrity of the brain. Neurotoxicology 48:9-20
Choi, Joungil; Chandrasekaran, Krish; Demarest, Tyler G et al. (2014) Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity. Ann Clin Transl Neurol 1:589-604
Raufman, Jean-Pierre; Xu, Su; Cheng, Kunrong et al. (2013) Phrygian Cap Appearance of a Mouse Gallbladder on Magnetic Resonance Imaging. J Vet Sci Med Diagn 2:
Zhuo, Jiachen; Xu, Su; Proctor, Julie L et al. (2012) Diffusion kurtosis as an in vivo imaging marker for reactive astrogliosis in traumatic brain injury. Neuroimage 59:467-77
Xu, Su; Zhuo, Jiachen; Racz, Jennifer et al. (2011) Early microstructural and metabolic changes following controlled cortical impact injury in rat: a magnetic resonance imaging and spectroscopy study. J Neurotrauma 28:2091-102
Raufman, Jean-Pierre; Xu, Su; Cheng, Kunrong et al. (2011) In vivo magnetic resonance imaging to detect biliary excretion of 19F-labeled drug in mice. Drug Metab Dispos 39:736-9