Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10RR021008-01
Application #
7166442
Study Section
Special Emphasis Panel (ZRG1-BPC-C (30))
Project Start
2005-04-01
Project End
2006-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
1
Fiscal Year
2005
Total Cost
$67,575
Indirect Cost
Name
State University New York Stony Brook
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
Lu, Rui; Schaefer, Christin M; Nesbitt, Natasha M et al. (2017) Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis Is Controlled by a Redox-Sensitive Thiol Switch. ACS Infect Dis 3:666-675
Schaefer, Christin M; Lu, Rui; Nesbitt, Natasha M et al. (2015) FadA5 a thiolase from Mycobacterium tuberculosis: a steroid-binding pocket reveals the potential for drug development against tuberculosis. Structure 23:21-33
Lu, Rui; Schmitz, Werner; Sampson, Nicole S (2015) ?-Methyl Acyl CoA Racemase Provides Mycobacterium tuberculosis Catabolic Access to Cholesterol Esters. Biochemistry 54:5669-72
Touchette, Megan H; Bommineni, Gopal R; Delle Bovi, Richard J et al. (2015) Diacyltransferase Activity and Chain Length Specificity of Mycobacterium tuberculosis PapA5 in the Synthesis of Alkyl ?-Diol Lipids. Biochemistry 54:5457-68
Yang, Meng; Lu, Rui; Guja, Kip E et al. (2015) Unraveling Cholesterol Catabolism in Mycobacterium tuberculosis: ChsE4-ChsE5 ?2?2 Acyl-CoA Dehydrogenase Initiates ?-Oxidation of 3-Oxo-cholest-4-en-26-oyl CoA. ACS Infect Dis 1:110-125
Yang, Meng; Guja, Kip E; Thomas, Suzanne T et al. (2014) A distinct MaoC-like enoyl-CoA hydratase architecture mediates cholesterol catabolism in Mycobacterium tuberculosis. ACS Chem Biol 9:2632-45
Gao, Jin; Sampson, Nicole S (2014) A GMC oxidoreductase homologue is required for acetylation of glycopeptidolipid in Mycobacterium smegmatis. Biochemistry 53:611-3
Wipperman, Matthew F; Sampson, Nicole S; Thomas, Suzanne T (2014) Pathogen roid rage: cholesterol utilization by Mycobacterium tuberculosis. Crit Rev Biochem Mol Biol 49:269-93
Su, Chiao-Yung; London, Erwin; Sampson, Nicole S (2013) Mapping peptide thiol accessibility in membranes using a quaternary ammonium isotope-coded mass tag (ICMT). Bioconjug Chem 24:1235-47
Thomas, Suzanne T; Sampson, Nicole S (2013) Mycobacterium tuberculosis utilizes a unique heterotetrameric structure for dehydrogenation of the cholesterol side chain. Biochemistry 52:2895-904

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