This proposal requests funding to acquire a high field-strength small animal magnetic resonance imaging (MRI) scanner, which will form the central component of a comprehensive small animal MRI facility at the University of Utah. The instrument proposed is a Bruker ClinScanZ B-C 70/30 USR (Ultra-Shielded, Refrigerated) high-resolution imaging system. Key technical features of the system include a 7.05 Tesla actively-shielded magnet, 30.2 cm magnetic clear bore size, a 20.1 cm inner-diameter base gradient system capable of 300 mT/m, 8-channel 1H spectrometer electronics, a Siemens MRI console, and in vivo imaging accessories. The University of Utah is a leader in genetic analysis of human disease and has been at the forefront in both generating and studying mice with targeted gene alterations. MRI's noninvasive nature and unparalleled soft-tissue contrast have made it a modality of choice for anatomical and physiological imaging of these genetically engineered animals. MRI imaging in small animals faces technical challenges related to requirements for high-resolution (e.g., SNR and spatial resolution tradeoff) and animal physiological considerations (e.g., high heart rates, motion). Moreover, quantitative interpretation of MR images often necessitates sophisticated post-processing and analysis (e.g., 3D visualization, registration). An innovative aspect of this proposal is that it will take advantage of the novel and innovative MRI technology development and image display/analysis research (largely funded by NIH) ongoing at the University of Utah. The proposed core MRI facility will leverage the strengths of the Utah Center for Advanced Imaging Research (UCAIR) and Scientific Computing and Imaging Institute (SCI). The integration of these technical resources in the operation and organizational infrastructure of the proposed high-field strength small animal imaging MRI facility will provide significant value-added benefits to its users. There are several NIH funded research projects at the University of Utah that currently utilize limited forms of small animal MRI, and many more NIH funded investigators that have clear but unmet small animal MRI needs. There is currently no dedicated up-to-date small animal MRI scanner in the state of Utah. Consequently, the instrument will have a profound impact on existing NIH funded projects and initiating new research projects at the University of Utah and beyond. ? ? ?

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-SBIB-N (30))
Program Officer
Tingle, Marjorie
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Utah
Biomedical Engineering
Schools of Engineering
Salt Lake City
United States
Zip Code
Gomez, Arnold D; Zou, Huashan; Bowen, Megan E et al. (2017) Right Ventricular Fiber Structure as a Compensatory Mechanism in Pressure Overload: A Computational Study. J Biomech Eng 139:
Abdullah, Osama M; Gomez, Arnold David; Merchant, Samer et al. (2016) Orientation dependence of microcirculation-induced diffusion signal in anisotropic tissues. Magn Reson Med 76:1252-62
Merchant, Samer S; Gomez, Arnold David; Morgan, James L et al. (2016) Parametric Modeling of the Mouse Left Ventricular Myocardial Fiber Structure. Ann Biomed Eng 44:2661-73
Abdullah, Osama M; Seidel, Thomas; Dahl, MarJanna et al. (2016) Diffusion tensor imaging and histology of developing hearts. NMR Biomed 29:1338-49
Mao, Haojie; Unnikrishnan, Ginu; Rakesh, Vineet et al. (2015) Untangling the Effect of Head Acceleration on Brain Responses to Blast Waves. J Biomech Eng 137:124502
Welsh, Christopher L; DiBella, Edward V R; Hsu, Edward W (2015) Higher-Order Motion-Compensation for In Vivo Cardiac Diffusion Tensor Imaging in Rats. IEEE Trans Med Imaging 34:1843-53
David Gomez, Arnold; Bull, David A; Hsu, Edward W (2015) Finite-Element Extrapolation of Myocardial Structure Alterations Across the Cardiac Cycle in Rats. J Biomech Eng 137:101010
Abdullah, Osama M; Drakos, Stavros G; Diakos, Nikolaos A et al. (2014) Characterization of diffuse fibrosis in the failing human heart via diffusion tensor imaging and quantitative histological validation. NMR Biomed 27:1378-86
Zinkhan, Erin K; Lang, Brook Y; Yu, Baifeng et al. (2014) Maternal tobacco smoke increased visceral adiposity and serum corticosterone levels in adult male rat offspring. Pediatr Res 76:17-23
Gomez, Arnold D; Merchant, Samer S; Hsu, Edward W (2014) Accurate high-resolution measurements of 3-D tissue dynamics with registration-enhanced displacement encoded MRI. IEEE Trans Med Imaging 33:1350-62

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