This revised application for an Advanced Research Cooperation in Environmental Health (ARCH) grant links the University of Texas at El Paso (UTEP), a Minority Serving Institution (MSI), with the University of New Mexico Health Sciences Center (UNM HSC), a Research Intensive University (RIU). The central research hypothesis is that children breathing air in the most polluted parts of El Paso, TX, have an increased prevalence of asthma, which may be under detected in the area's medically underserved Hispanic children. The project builds on the research strengths and previous work of UTEP investigators in documenting significant air and soil pollution problems in El Paso, TX, and contiguous Juarez, Mexico, and on UTEP's recent successful programs in public health. The Core Research Project ties high-density (both spatial and temporal) air and soil quality data to the prevalence and intensity of asthma and respiratory distress in a cohort of 1200 households randomly selected from 100 stratified blocks in the El Paso community. The application has been completely revised with an improved environmental sampling design, development of a more expansive cohort, new environmental epidemiology expertise, and more productive interactions of all Pilot Projects with the Core Research Project. The Pilot Projects will monitor levels of pollutants, including PM2.5, carbon nanoparticles, toxic metals, polycyclic aromatic hydrocarbons (PAHs), atmospheric ozone, nitrogen dioxide (NO2), and volatile organic compounds (VOCs), and feed these data to the Research Core. In revised Project 1, lung function in children measured by Impulse Oscillometry (IOS) methods in a clinical setting will be compared to lung function measured with spirometry methods promotoras in the local communities. Project 2 is new and examines the relationship between indoor and outdoor air sample particle concentration and composition in a subset of the blocks in the Research Core Project. Project 3 is also new and will test for gases (NO2, ozone, and VOCs), again in neighborhoods tied to the Core. Revised Project 4 examines the hypothesis that the organic fraction of PM2.5 contributes to asthma via oxidized PAHs that activate cell signaling pathways important in inflammation and immediate type hypersensitivity leading to asthma exacerbations. Project 5 performs innovative studies on carbon nanotubes from local environmental sources. The ARCH Program is overseen by an Administrative Core and is supported by a Facility Core at UTEP.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Minority Biomedical Research Support Thematic Project Grants (S11)
Project #
Application #
Study Section
Special Emphasis Panel (ZES1-LWJ-B (AR))
Program Officer
Tyson, Frederick L
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas El Paso
Organized Research Units
El Paso
United States
Zip Code
Rocha-GutiƩrrez, Beatriz A; Lee, Wen-Yee; Shane Walker, W (2016) Mass balance and mass loading of polybrominated diphenyl ethers (PBDEs) in a tertiary wastewater treatment plant using SBSE-TD-GC/MS. Water Sci Technol 73:302-8
Olvera, Hector A; Lopez, Mario; Guerrero, Veronica et al. (2013) Ultrafine particle levels at an international port of entry between the US and Mexico: exposure implications for users, workers, and neighbors. J Expo Sci Environ Epidemiol 23:289-98
Olvera, Hector A; Perez, Daniel; Clague, Juan W et al. (2012) The effect of ventilation, age, and asthmatic condition on ultrafine particle deposition in children. Pulm Med 2012:736290
Gonzales, Melissa; Myers, Orrin; Smith, Luther et al. (2012) Evaluation of land use regression models for NO2 in El Paso, Texas, USA. Sci Total Environ 432:135-42
Olvera, Hector A; Garcia, Mario; Li, Wen-Whai et al. (2012) Principal component analysis optimization of a PM2.5 land use regression model with small monitoring network. Sci Total Environ 425:27-34
Meraz, Erika G; Nazeran, Homer; Ramos, Carlos D et al. (2011) Analysis of impulse oscillometric measures of lung function and respiratory system model parameters in small airway-impaired and healthy children over a 2-year period. Biomed Eng Online 10:21
Yamaguchi, Chika; Lee, Wen-Yee (2010) A cost effective, sensitive, and environmentally friendly sample preparation method for determination of polycyclic aromatic hydrocarbons in solid samples. J Chromatogr A 1217:6816-23
Goldman, Michael D; Nazeran, Homer; Ramos, Carlos et al. (2010) Electrical circuit models of the human respiratory system reflect small airway impairment measured by impulse oscillation (IOS). Conf Proc IEEE Eng Med Biol Soc 2010:2467-72
Staniswalis, Joan G; Yang, Hongling; Li, Wen-Whai et al. (2009) Using a continuous time lag to determine the associations between ambient PM2.5 hourly levels and daily mortality. J Air Waste Manag Assoc 59:1173-85
Pingitore Jr, Nicholas E; Clague, Juan W; Amaya, Maria A et al. (2009) Urban airborne lead: X-ray absorption spectroscopy establishes soil as dominant source. PLoS One 4:e5019

Showing the most recent 10 out of 21 publications